关节内透明质酸制剂流变学特性与报道的人滑膜液的比较。

A Comparison Between Rheological Properties of Intra-articular Hyaluronic Acid Preparations and Reported Human Synovial Fluid.

机构信息

Virginia Mason Orthopedics and Sports Medicine, Seattle, WA, USA.

Division of Orthopaedics, McMaster University, Hamilton, ON, Canada.

出版信息

Adv Ther. 2018 Apr;35(4):523-530. doi: 10.1007/s12325-018-0688-y. Epub 2018 Mar 14.

DOI:10.1007/s12325-018-0688-y

PMID:29542009

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5910459/

Abstract

INTRODUCTION

This study aims to compare the properties of currently available intra-articular hyaluronate (IA-HA) products widely available in the USA to those of healthy knee synovial fluid with respect to their bulk rheological properties. We hypothesize that products would have differing rheological properties, with some more closely resembling the properties and physiological aspects of healthy joint fluid HA.

METHODS

We obtained reported HA product molecular weights, as well as measurements of the presence of cross-linking, zero shear rate viscosity, shear thinning ratio, and crossover frequency for the following IA-HA products available in the USA: Euflexxa, Orthovisc, Supartz, Monovisc, Synvisc, Synvisc-One, Gel-One, and Hyalgan.

RESULTS

Differences were seen between the study products across all of the investigated parameters. Hyalgan, Supartz, Orthovisc, and Euflexxa had a linear chain structure, while Synvisc, Synvisc-One, and Monovisc were cross-linked in structure. Molecular weight, shear rates, and crossover frequencies ranged widely across tested products, with values ranging from below to above those reported for healthy knee synovial fluid HA. When compared to healthy knee parameter values reported within the current literature, observed parameters for Euflexxa and Orthovisc were typically seen to be the most similar to healthy knee synovial fluid. When comparing Euflexxa and Orthovisc directly, Euflexxa was more often similar to the properties of healthy knee synovial fluid with respect to the observed parameters of molecular structure, shear rates, and crossover frequency.

CONCLUSION

Available IA-HA products vary with respect to molecular weight, presence of cross-linking, shear rate dependency of viscosity, and crossover frequency. Since IA-HA treatment for osteoarthritis aims to restore synovial fluid back to original HA property characteristics, using HA supplements resembling healthy synovial fluid is a logical approach. Our findings demonstrate that Euflexxa is the most similar to healthy synovial fluid with respect to molecular structure, shear rates, and crossover frequency.

FUNDING

Ferring Pharmaceuticals, Inc.

摘要

简介

本研究旨在比较目前在美国广泛应用的关节内透明质酸（IA-HA）产品与健康膝关节滑液的特性，特别是在其整体流变特性方面。我们假设这些产品将具有不同的流变特性，其中一些更接近健康关节液 HA 的特性和生理方面。

方法

我们获得了报告的 HA 产品分子量，以及对以下在美国可用的 IA-HA 产品的存在交联、零剪切速率粘度、剪切稀化比和交叉频率的测量：Euflexxa、Orthovisc、Supartz、Monovisc、Synvisc、Synvisc-One、Gel-One 和 Hyalgan。

结果

在所研究的参数中，研究产品之间存在差异。Hyalgan、Supartz、Orthovisc 和 Euflexxa 具有线性链结构，而 Synvisc、Synvisc-One 和 Monovisc 结构交联。分子量、剪切速率和交叉频率在测试产品中广泛变化，其值范围从低于报道的健康膝关节滑液 HA 值到高于该值。与当前文献中报道的健康膝关节参数值相比，观察到的 Euflexxa 和 Orthovisc 参数通常与健康膝关节滑液最相似。当直接比较 Euflexxa 和 Orthovisc 时，Euflexxa 在分子结构、剪切速率和交叉频率的观察参数方面更常与健康膝关节滑液的特性相似。

结论

可用的 IA-HA 产品在分子量、交联存在、粘度对剪切速率的依赖性和交叉频率方面存在差异。由于 IA-HA 治疗骨关节炎旨在将滑液恢复到原始 HA 特性，因此使用类似于健康滑液的 HA 补充剂是一种合理的方法。我们的研究结果表明，Euflexxa 在分子结构、剪切速率和交叉频率方面与健康滑液最相似。