Lázaro Beatriz, Alonso Prudencio, Rodriguez Andrea, La Nuez Manuel, Marzo Florencio, Prieto Julio G
Biomedical Sciences Department, University of León, Spain.
Public University of Navarre, Spain.
Biorheology. 2018;55(1):41-50. doi: 10.3233/BIR-180174.
Hyaluronic acid (HA) is a polysaccharide present in almost all animal tissues, in which it carries out important biological functions, among them, the protection of the joints by lubricating them and dampening the tension in them.
This study compares the viscoelastic properties of several commercial preparations of HA, to determine their suitability for use as viscosupplementation therapy in joint pathology (osteoarthritis).
4 HA hydrogels: Durolane®, Synocrom_Forte_One®, Synvisc_One® and Viscoplus_Matrix® and 4 HA solutions: Ostenil®, Ostenil_Plus®, Viscoplus_Gel® and Orthovisc® were analyzed to compare their viscoelatsic rheological parameters using an oscillatory-rotational rheometer.
With respect to the 4 HA hydrogels, comparison of crossover frequencies allowed division into two main groups: Synvisc_One® and Viscoplus_Matrix®, with crossover frequencies in the order of magnitude of 10-2 Hz, while Synocrom_Forte_One® and Durolane® showed crossover frequencies on the order of 10-1 Hz. Only one of the 4 HA solutions, Viscoplus_Gel®, showed a crossover frequency on the order of 10-2, whereas Ostenil_Plus® and Orthovisc® showed crossover frequencies on the order of 10-1, and Ostenil® remained as a predominantly viscous fluid for frequencies as high as 4.8 Hz.
The viscoelastic properties of the HA preparations can be ordered according to the values of G∗ (the rigidity, or vector sum of the elastic modulus G' and the viscous modulus G'') at both transition points (0.5 and 2.5 Hz) as follows: Viscoplus_Matrix® > Viscoplus_Gel® > Durolane® > Synocrom_Forte_One® > Ostenil_Plus® > Synvisc_One® > Orthovisc® > Ostenil®.
透明质酸（HA）是一种存在于几乎所有动物组织中的多糖，在这些组织中它发挥着重要的生物学功能，其中包括通过润滑关节和缓冲关节内的张力来保护关节。
本研究比较了几种市售透明质酸制剂的粘弹性特性，以确定它们在关节疾病（骨关节炎）中作为粘弹性补充疗法的适用性。
分析了4种透明质酸水凝胶：Durolane®、Synocrom_Forte_One®、Synvisc_One®和Viscoplus_Matrix®，以及4种透明质酸溶液：Ostenil®、Ostenil_Plus®、Viscoplus_Gel®和Orthovisc®，使用振荡旋转流变仪比较它们的粘弹性流变学参数。
对于4种透明质酸水凝胶，通过比较交叉频率可分为两个主要组：Synvisc_One®和Viscoplus_Matrix®，交叉频率在10⁻²Hz量级，而Synocrom_Forte_One®和Durolane®的交叉频率在10⁻¹Hz量级。4种透明质酸溶液中只有Viscoplus_Gel®的交叉频率在10⁻²量级，而Ostenil_Plus®和Orthovisc®的交叉频率在10⁻¹量级，Ostenil®在高达4.8Hz的频率下仍主要表现为粘性流体。
透明质酸制剂的粘弹性特性可根据在两个转变点（0.5和2.5Hz）的G∗值（刚度，即弹性模量G'和粘性模量G''的矢量和）按以下顺序排列：Viscoplus_Matrix® > Viscoplus_Gel® > Durolane® > Synocrom_Forte_One® > Ostenil_Plus® > Synvisc_One® > Orthovisc® > Ostenil®。
