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熔球态概念:45年后

The Molten Globule Concept: 45 Years Later.

作者信息

Bychkova V E, Semisotnov G V, Balobanov V A, Finkelstein A V

机构信息

Institute of Protein Research, Pushchino, Moscow Region, 142290, Russia.

出版信息

Biochemistry (Mosc). 2018 Jan;83(Suppl 1):S33-S47. doi: 10.1134/S0006297918140043.

DOI:10.1134/S0006297918140043
PMID:29544429
Abstract

In this review, we describe traditional systems where the molten globule (MG) state has been detected and give a brief description of the solution of Levinthal's paradox. We discuss new results obtained for MG-mediated folding of "nontraditional" proteins and a possible functional role of the MG. We also report new data on the MG, especially the dry molten globule.

摘要

在本综述中,我们描述了已检测到熔球态(MG)的传统体系,并简要介绍了莱文索尔悖论的解决方案。我们讨论了关于MG介导的“非传统”蛋白质折叠的新结果以及MG可能的功能作用。我们还报告了关于MG的新数据,特别是干燥熔球态的数据。

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The Molten Globule Concept: 45 Years Later.熔球态概念:45年后
Biochemistry (Mosc). 2018 Jan;83(Suppl 1):S33-S47. doi: 10.1134/S0006297918140043.
2
Solution of Levinthal's Paradox and a Physical Theory of Protein Folding Times.莱文索尔佯谬的解决与蛋白质折叠时间的物理理论。
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How A Novel Scientific Concept Was Coined the "Molten Globule State".如何创造一个新的科学概念——“熔融球状态”。
Biomolecules. 2020 Feb 10;10(2):269. doi: 10.3390/biom10020269.
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Protein structure: Has Levinthal's paradox "folded"?蛋白质结构:莱文索尔悖论“解决”了吗?
FASEB J. 2021 Mar;35(3):e21416. doi: 10.1096/fj.202100136.
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[How many molten globules states exist?].[存在多少种熔球态?]
Biofizika. 1998 May-Jun;43(3):416-21.
6
Structural energetics of the molten globule state.熔球态的结构能量学
Proteins. 1993 Jun;16(2):115-40. doi: 10.1002/prot.340160202.
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Volumetric characterizations of the native, molten globule and unfolded states of cytochrome c at acidic pH.细胞色素c在酸性pH值下天然态、熔球态和去折叠态的体积表征。
J Mol Biol. 1995 Jul 7;250(2):291-306. doi: 10.1006/jmbi.1995.0377.
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50+ Years of Protein Folding.50 多年的蛋白质折叠研究
Biochemistry (Mosc). 2018 Jan;83(Suppl 1):S3-S18. doi: 10.1134/S000629791814002X.
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Reduction of the Search Space for the Folding of Proteins at the Level of Formation and Assembly of Secondary Structures: A New View on the Solution of Levinthal's Paradox.在二级结构形成和组装层面减少蛋白质折叠的搜索空间:对莱文索尔悖论解决方案的新观点。
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Molten globules, entropy-driven conformational change and protein folding.无定形球,熵驱动的构象变化和蛋白质折叠。
Curr Opin Struct Biol. 2013 Feb;23(1):4-10. doi: 10.1016/j.sbi.2012.11.004. Epub 2012 Dec 10.

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