前列腺素A抑制牛病毒性腹泻病毒的复制。

Prostaglandin A inhibits the replication of bovine viral diarrhea virus.

作者信息

Caldas Lúcio Ayres, Freitas Tânia Rosária Pereira, Azevedo Renata Campos, de Souza Wanderley

机构信息

Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMETRO), Rio de Janeiro, RJ, Brazil.

Ministério da Agricultura, Pecuária e Abastecimento, Laboratório Nacional Agropecuário - LANAGRO - MG, Pedro Leopoldo, MG, Brazil.

出版信息

Braz J Microbiol. 2018 Oct-Dec;49(4):785-789. doi: 10.1016/j.bjm.2017.12.010. Epub 2018 Mar 1.

DOI:10.1016/j.bjm.2017.12.010

PMID:29544983

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6175701/

Abstract

Bovine viral diarrhea virus can cause acute disease in livestock, leading to economic losses. We show that Prostaglandin A inhibits bovine viral diarrhea virus replication in Madin-Darby bovine kidney cells (94% inhibition using 5μg/mL). Light and electron microscopy of infected cells shows that Prostaglandin A also prevents virus-induced vacuolization, but at higher concentrations (10μg/mL).

摘要

牛病毒性腹泻病毒可导致家畜患急性疾病，造成经济损失。我们发现，前列腺素A可抑制牛病毒性腹泻病毒在马-达二氏牛肾细胞中的复制（5μg/mL时抑制率达94%）。对受感染细胞进行光学显微镜和电子显微镜观察发现，前列腺素A还可防止病毒诱导的空泡化，但需要更高的浓度（10μg/mL）。