前列腺素A1对持续感染经典猪瘟病毒的猪细胞的影响。
Effect of prostaglandin A1 in porcine cells persistently infected with classical swine fever virus.
作者信息
Freitas Tânia Rosária Pereira, Caldas Lúcio Ayres, Rebello Moacyr Alcoforado
机构信息
Institute of Microbiology Professor Paulo de Góes, CCS, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, CEP: 21941-590, Brazil.
出版信息
J Basic Microbiol. 2003;43(6):468-72. doi: 10.1002/jobm.200310295.
Cyclopentenone prostaglandins are potent inhibitors of a wide variety of RNA and DNA viruses. In this report we describe that prostaglandin A1 (PGA1) potently inhibited the replication of classical swine fever virus in cultures of PK-15 cells. The highest non-toxic dose (5 microg/ml) inhibited virus yield in 99% at the initial phase of infection and in 77% in persistent infected cells. However when PGA1 was removed from persistently infected cells, the inhibition of virus replication was partially reverted.
环戊烯酮前列腺素是多种RNA和DNA病毒的强效抑制剂。在本报告中，我们描述了前列腺素A1（PGA1）在PK - 15细胞培养物中能有效抑制经典猪瘟病毒的复制。最高无毒剂量（5微克/毫升）在感染初期抑制病毒产量达99%，在持续感染细胞中抑制率为77%。然而，当从持续感染细胞中去除PGA1时，病毒复制的抑制作用部分恢复。
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