King's College London, Department of Global Health and Social Medicine, London, United Kingdom.
Universidade Federal de Pernambuco, Departamento de Genética, Recife, PE, Brazil.
Braz J Infect Dis. 2018 Mar-Apr;22(2):137-141. doi: 10.1016/j.bjid.2018.02.005. Epub 2018 Mar 12.
Zika virus (ZIKV) is an emergent flavivirus transmitted mainly through Aedes spp. mosquitoes that is posing challenge to healthcare services in countries experiencing an outbreak. Usually ZIKV infection is mild, but in some cases it has been reported to progress into neurological diseases such as microcephaly in infants and Guillain-Barré syndrome (GBS) in adults. GBS is a debilitating autoimmune disorder that affects peripheral nerves. Since ZIKV caused massive outbreaks in South America in the past few years, we aimed to systematically review the literature and perform a meta-analysis to estimate the prevalence of GBS among ZIKV-infected individuals. We searched PubMed and Cochrane databases and selected three studies for a meta-analysis. We estimated the prevalence of ZIKV-associated GBS to be 1.23% (95% CI=1.17-1.29%). Limitations include paucity of data regarding previous flavivirus infections and ZIKV-infection confirmation issues. Our estimate seems to be low, but cannot be ignored, since ZIKV outbreaks affects an overwhelming number of individuals and GBS is a life-threatening debilitating condition, especially in pregnant women. ZIKV infection cases must be closely followed to assure prompt care to reduce the impact of GBS associated-sequelae on the quality of life of those affected.
Zika 病毒（ZIKV）是一种主要通过埃及伊蚊传播的新兴黄病毒，它对正在经历疫情爆发的国家的医疗服务构成了挑战。通常，ZIKV 感染是轻微的，但在某些情况下，它已被报告进展为神经疾病，如婴儿小头畸形和成人格林-巴利综合征（GBS）。GBS 是一种使人衰弱的自身免疫性疾病，影响外周神经。由于 ZIKV 在过去几年在南美洲造成了大规模爆发，我们旨在系统地审查文献并进行荟萃分析，以估计 ZIKV 感染个体中 GBS 的患病率。我们搜索了 PubMed 和 Cochrane 数据库，并选择了三项研究进行荟萃分析。我们估计 ZIKV 相关 GBS 的患病率为 1.23%（95%CI=1.17-1.29%）。局限性包括缺乏关于先前黄病毒感染和 ZIKV 感染确认问题的数据。我们的估计似乎较低，但不能忽视，因为 ZIKV 爆发影响了大量的个体，并且 GBS 是一种危及生命的使人衰弱的疾病，特别是在孕妇中。必须密切关注 ZIKV 感染病例，以确保及时提供护理，从而减少 GBS 相关后遗症对受影响者生活质量的影响。
