Frost J James, Pienta Kenneth J, Coffey Donald S
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
James Buchanan Brady Urological Institute at the Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Oncotarget. 2017 Dec 5;9(14):11429-11440. doi: 10.18632/oncotarget.22939. eCollection 2018 Feb 20.
Symmetry and symmetry breaking concepts from physics and biology are applied to the problem of cancer. Three categories of symmetry breaking in cancer are examined: combinatorial, geometric, and functional. Within these categories, symmetry breaking is examined for relevant cancer features, including epithelial-mesenchymal transition (EMT); tumor heterogeneity; tensegrity; fractal geometric and information structure; functional interaction networks; and network stabilizability and attack tolerance. The new cancer symmetry concepts are relevant to homeostasis loss in cancer and to its origin, spread, treatment and resistance. Symmetry and symmetry breaking could provide a new way of thinking and a pathway to a solution of the cancer problem.
来自物理学和生物学的对称与对称破缺概念被应用于癌症问题。研究了癌症中三类对称破缺：组合型、几何型和功能型。在这些类别中，针对相关癌症特征研究对称破缺，包括上皮-间质转化（EMT）；肿瘤异质性；张拉整体结构；分形几何和信息结构；功能相互作用网络；以及网络稳定性和抗攻击能力。新的癌症对称概念与癌症中的稳态丧失及其起源、扩散、治疗和耐药性相关。对称与对称破缺可为思考癌症问题提供新方式和解决途径。
