使用自组装肽（PuraStat）对吻合口溃疡的影响——一项多中心病例系列研究

Oza Veeral M, Mittal Nitish, Winchester Charles, Fazel Yousef, Manvar Amar, Goodman Adam, Girotra Mohit, Khara Harshit S, Kothari Shivangi, Kothari Truptesh H

Bon Secours Mercy Health, Gastroenterology and Liver Disease, Greenville, SC.

Division of Gastroenterology, Hepatology, and Nutrition, The University of Texas Health Sciences Center, Houston, TX.

ACG Case Rep J. 2024 Oct 10;11(10):e01535. doi: 10.14309/crj.0000000000001535. eCollection 2024 Oct.

Treatment of anastomotic ulcers, also known as marginal ulcers, is challenging, especially when established techniques have failed. PuraStat is a biocompatible synthetic peptide gel that is indicated for hemostasis of bleeding in the gastrointestinal tract and vascular anastomoses. We aim to evaluate the feasibility of PuraStat in the setting of nonhealing anastomotic ulcers when used alongside standard therapies. This is a multicenter case series of adult patients who had PuraStat applied with a follow-up repeat endoscopy. Nine out of 10 patients showed clinical improvement. We concluded that PuraStat is an effective agent to aid in healing of anastomotic ulcer.

吻合口溃疡（也称为边缘溃疡）的治疗具有挑战性，尤其是在现有技术治疗失败时。PuraStat是一种生物相容性合成肽凝胶，适用于胃肠道和血管吻合口出血的止血。我们旨在评估PuraStat与标准疗法联合用于不愈合吻合口溃疡时的可行性。这是一个多中心病例系列，纳入了应用PuraStat并接受随访重复内镜检查的成年患者。10名患者中有9名显示出临床改善。我们得出结论，PuraStat是有助于吻合口溃疡愈合的有效药物。