中国东北地区 Graves 病伴或不伴眼病患者的血清微量元素谱。
Serum Trace Elements Profile in Graves' Disease Patients with or without Orbitopathy in Northeast China.
机构信息
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, No. 155, North Nanjing Street, Heping District, Shenyang, China.
Department of Emergency, No. 202 Hospital of People's Liberation Army, No. 5, Guangrong Street, Heping District, Shenyang, China.
出版信息
Biomed Res Int. 2018 Jan 10;2018:3029379. doi: 10.1155/2018/3029379. eCollection 2018.
OBJECTIVE
The purpose of the present study was to investigate serum trace elements in Graves' disease (GD) patients with or without orbitopathy in Northeast China.
METHODS
Patients with newly diagnosed Graves' disease (HyGD) ( = 66), GD patients with euthyroid status or subclinical thyroidism after treatment (EUGD) ( = 55), GO patients with euthyroid status or subclinical thyroidism after treatment (GO) ( = 57), and normal controls (NC) ( = 66) were enrolled in this study. Serum trace elements were measured with ICP-MS.
RESULTS
Serum selenium (Se) levels in EUGD group (median: 7.53 g/dL), HyGD group (median: 6.76 g/dL), and GO group (median: 7.40 g/dL) were significantly lower than those in NC group (median: 9.20 g/dL, all < 0.01). Serum copper (Cu) levels in GO group (median: 95.93 g/dL) were significantly lower than those in the NC group (median: 113.59 g/dL, = 0.015). After being adjusted for multivariables, thyroid-specific antibodies grade was associated with low Se levels. Hyperthyroidism and thyroid-specific antibodies grade were associated with high Cu levels. In addition, orbitopathy was associated with low Cu levels.
CONCLUSIONS
Thyroid autoimmunity was associated with low Se levels. Hyperthyroidism and thyroid autoimmunity may be associated with relatively high serum Cu levels. Alternatively, ophthalmopathy may be related to low serum Cu levels.
目的
本研究旨在探讨中国东北地区 Graves 病（GD）患者伴或不伴眼病时的血清微量元素情况。
方法
本研究纳入了 66 例初诊 GD 患者（HyGD）、55 例 GD 患者经治疗后甲状腺功能正常或亚临床甲状腺功能减退（EUGD）、57 例 GO 患者经治疗后甲状腺功能正常或亚临床甲状腺功能减退（GO）和 66 例正常对照者（NC）。采用 ICP-MS 检测血清微量元素。
结果
EUGD 组（中位数：7.53μg/dL）、HyGD 组（中位数：6.76μg/dL）和 GO 组（中位数：7.40μg/dL）的血清硒（Se）水平均显著低于 NC 组（中位数：9.20μg/dL，均 < 0.01）。GO 组的血清铜（Cu）水平（中位数：95.93μg/dL）显著低于 NC 组（中位数：113.59μg/dL， = 0.015）。在校正了多变量后，甲状腺特异性抗体分级与低 Se 水平相关。甲亢和甲状腺特异性抗体分级与高 Cu 水平相关。此外，眼病与低 Cu 水平相关。
结论
甲状腺自身免疫与低 Se 水平有关。甲亢和甲状腺自身免疫可能与相对较高的血清 Cu 水平有关。相反，眼病可能与低血清 Cu 水平有关。
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