真菌分泌：抗真菌药物的新一代靶点？

Fungal Secretion: The Next-Gen Target of Antifungal Agents?

机构信息

Centre for Infectious Diseases and Microbiology, The Westmead Institute for Medical Research, 176 Hawkesbury Road, Westmead, NSW 2145, Australia; Sydney Medical School - Westmead, University of Sydney, Westmead, NSW 2145, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, NSW, Australia.

出版信息

Cell Chem Biol. 2018 Mar 15;25(3):233-235. doi: 10.1016/j.chembiol.2018.02.015.

DOI:10.1016/j.chembiol.2018.02.015

PMID:29547713

Abstract

Invasive fungal diseases pose a serious threat, and new drugs are urgently needed. In this issue of Cell Chemical Biology, Pries et al. (2018) identified benzamide- and picolinamide-based small-molecule inhibitors with antifungal properties, including some active against pathogenic Candida species. These compounds target an essential component of the fungal secretion machinery, suggesting a new approach to antifungal development.

摘要

侵袭性真菌病构成严重威胁，急需新药。在本期《细胞化学生物学》中，Pries 等人（2018）鉴定出具有抗真菌特性的苯甲酰胺和吡啶甲酰胺为基础的小分子抑制剂，其中一些对致病性念珠菌属物种具有活性。这些化合物以真菌分泌机制的一个必需组分为靶标，提示了一种新的抗真菌药物研发方法。