Centro de Investigación y Asistencia en Tecnología y diseño del Estado de Jalisco, A.C., Biotecnología Médica y Farmacéutica, Av. Normalistas 800, Col. Colinas de la Normal, Guadalajara, Jalisco 44270, México.
Centro de Investigación y Asistencia en Tecnología y diseño del Estado de Jalisco, A.C., Biotecnología Médica y Farmacéutica, Av. Normalistas 800, Col. Colinas de la Normal, Guadalajara, Jalisco 44270, México; Doctorado en Farmacología, Universidad de Guadalajara, Sierra Mojada 950, Col. Independencia Oriente 44340, Guadalajara, Jalisco, Mexico.
Mol Immunol. 2018 May;97:16-19. doi: 10.1016/j.molimm.2018.03.006. Epub 2018 Mar 14.
Effective prevention of tuberculosis (Tb) would undoubtedly be of paramount relevance in the control of its global burden, which resulted in more than 6 million new cases in 2016. Research aimed to improve the current vaccine, Bacillus Calmette- Guérin (BCG), or directed to develop new candidates, has taken into account the interaction between the host and Mycobacterium tuberculosis (Mtb). Recently, autophagy, an intracellular process of the host, has been shown to act as a mechanism that contributes to bacilli clearance in vitro and in vivo. Stimulation of autophagy, if correctly balanced, is an approach that has the potential to enhance the immune response of the host, and offers new avenues for developing immunogens that may give an improved protection upon immunization, given that in fact, some recent rBCG vaccine candidates have been shown to modulate autophagy. In this Discussion, we analyze the role of autophagy in the context of mycobacterial infection, its modulation via mycobacterial elements, and the management of host response as an alternative to develop new, hopefully improved, Tb-vaccine candidates.
有效的结核病（TB）预防无疑对控制其全球负担至关重要，2016 年全球有超过 600 万例新发病例。旨在改善目前的疫苗卡介苗（BCG）或开发新候选疫苗的研究，已经考虑到宿主与结核分枝杆菌（Mtb）之间的相互作用。最近，宿主的细胞内过程自噬被证明是一种有助于体外和体内杆菌清除的机制。如果正确平衡自噬的刺激，是一种有可能增强宿主免疫反应的方法，并为开发免疫原提供了新的途径，因为事实上，一些最近的 rBCG 疫苗候选物已被证明可以调节自噬。在本次讨论中，我们分析了自噬在分枝杆菌感染背景下的作用、分枝杆菌成分对其的调节以及宿主反应的管理，作为开发新的、有希望改进的 TB 疫苗候选物的替代方法。
