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用于质子笔形束扫描每日质量保证的专用体模的距离分辨率和可重复性

Range resolution and reproducibility of a dedicated phantom for proton PBS daily quality assurance.

作者信息

Placidi Lorenzo, Togno Michele, Weber Damien C, Lomax Antony J, Hrbacek Jan

机构信息

Centre for Proton Therapy, Paul Scherrer Institut, 5232 Villigen, Switzerland.

IBA Dosimetry, Schwarzenbruck, Germany.

出版信息

Z Med Phys. 2018 Dec;28(4):310-317. doi: 10.1016/j.zemedi.2018.02.001. Epub 2018 Mar 13.

Abstract

PURPOSE

Wedge phantoms coupled with a CCD camera are suggested as a simple means to improve the efficiency of quality assurance for pencil beam scanning (PBS) proton therapy, in particular to verify energy/range consistency on a daily basis. The method is based on the analysis of an integral image created by a pencil beam (PB) pattern delivered through a wedge. We have investigated the reproducibility of this method and its dependence on setup and positional beam errors for a commercially available phantom (Sphinx, IBA Dosimetry) and CCD camera (Lynx, IBA Dosimetry) system.

MATERIAL AND METHODS

The phantom includes 4 wedges of different thickness, allowing verification of the range for 4 energies within one integral image. Each wedge was irradiated with a line pattern of clinical energies (120, 150, 180 and 230MeV). The equipment was aligned to the isocenter using lasers, and the delivery was repeated for 5 consecutive days, 4 times each day. Range was computed using the myQA software (IBA Dosimetry) and inter- and intra-setup uncertainty were calculated. Dependence of range on energy was investigated delivering the same pencil beam pattern but with energy variations in steps of ±0.2MeV for all the nominal energies, up to ±1.0MeV. Possible range uncertainties, caused by setup and positional errors, were then simulated including inclination of the phantom, pencil beam and couch shifts.

RESULTS

Intra position setup (based on in-room laser system) shows a maximum in plane difference within 1.5mm. Range reproducibility (standard deviation) was less than 0.14mm. Setup and beam errors did not affect significantly the results, except for a vertical shift of 10mm which leads to an error in the range computation.

CONCLUSION

Taking into account different day-to-day setup and beam errors, day-to-day determination of range has been shown to be reproducible using the proposed system.

摘要

目的

楔形体模与电荷耦合器件(CCD)相机相结合,被认为是提高笔形束扫描(PBS)质子治疗质量保证效率的一种简单方法,特别是用于每日验证能量/射程的一致性。该方法基于对通过楔形物传递的笔形束(PB)图案创建的积分图像的分析。我们研究了这种方法的可重复性及其对市售体模(Sphinx,IBA剂量学)和CCD相机(Lynx,IBA剂量学)系统的设置和位置束流误差的依赖性。

材料与方法

该体模包括4个不同厚度的楔形物,可在一个积分图像内验证4种能量的射程。每个楔形物用临床能量(120、150、180和230MeV)的线图案进行照射。使用激光将设备对准等中心,并连续5天每天重复照射4次。使用myQA软件(IBA剂量学)计算射程,并计算设置间和设置内的不确定性。通过传递相同的笔形束图案,但所有标称能量的能量以±0.2MeV的步长变化,直至±1.0MeV,研究射程对能量的依赖性。然后模拟由设置和位置误差引起的可能的射程不确定性,包括体模倾斜、笔形束和治疗床移位。

结果

基于室内激光系统的位置内设置显示平面内最大差异在1.5mm以内。射程可重复性(标准差)小于0.14mm。设置和束流误差对结果没有显著影响,除了10mm的垂直位移会导致射程计算出现误差。

结论

考虑到不同的日常设置和束流误差,已证明使用所提出的系统每日确定射程具有可重复性。

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