Placidi Lorenzo, Togno Michele, Weber Damien C, Lomax Antony J, Hrbacek Jan
Centre for Proton Therapy, Paul Scherrer Institut, 5232 Villigen, Switzerland.
IBA Dosimetry, Schwarzenbruck, Germany.
Z Med Phys. 2018 Dec;28(4):310-317. doi: 10.1016/j.zemedi.2018.02.001. Epub 2018 Mar 13.
Wedge phantoms coupled with a CCD camera are suggested as a simple means to improve the efficiency of quality assurance for pencil beam scanning (PBS) proton therapy, in particular to verify energy/range consistency on a daily basis. The method is based on the analysis of an integral image created by a pencil beam (PB) pattern delivered through a wedge. We have investigated the reproducibility of this method and its dependence on setup and positional beam errors for a commercially available phantom (Sphinx, IBA Dosimetry) and CCD camera (Lynx, IBA Dosimetry) system.
The phantom includes 4 wedges of different thickness, allowing verification of the range for 4 energies within one integral image. Each wedge was irradiated with a line pattern of clinical energies (120, 150, 180 and 230MeV). The equipment was aligned to the isocenter using lasers, and the delivery was repeated for 5 consecutive days, 4 times each day. Range was computed using the myQA software (IBA Dosimetry) and inter- and intra-setup uncertainty were calculated. Dependence of range on energy was investigated delivering the same pencil beam pattern but with energy variations in steps of ±0.2MeV for all the nominal energies, up to ±1.0MeV. Possible range uncertainties, caused by setup and positional errors, were then simulated including inclination of the phantom, pencil beam and couch shifts.
Intra position setup (based on in-room laser system) shows a maximum in plane difference within 1.5mm. Range reproducibility (standard deviation) was less than 0.14mm. Setup and beam errors did not affect significantly the results, except for a vertical shift of 10mm which leads to an error in the range computation.
Taking into account different day-to-day setup and beam errors, day-to-day determination of range has been shown to be reproducible using the proposed system.
楔形体模与电荷耦合器件(CCD)相机相结合,被认为是提高笔形束扫描(PBS)质子治疗质量保证效率的一种简单方法,特别是用于每日验证能量/射程的一致性。该方法基于对通过楔形物传递的笔形束(PB)图案创建的积分图像的分析。我们研究了这种方法的可重复性及其对市售体模(Sphinx,IBA剂量学)和CCD相机(Lynx,IBA剂量学)系统的设置和位置束流误差的依赖性。
该体模包括4个不同厚度的楔形物,可在一个积分图像内验证4种能量的射程。每个楔形物用临床能量(120、150、180和230MeV)的线图案进行照射。使用激光将设备对准等中心,并连续5天每天重复照射4次。使用myQA软件(IBA剂量学)计算射程,并计算设置间和设置内的不确定性。通过传递相同的笔形束图案,但所有标称能量的能量以±0.2MeV的步长变化,直至±1.0MeV,研究射程对能量的依赖性。然后模拟由设置和位置误差引起的可能的射程不确定性,包括体模倾斜、笔形束和治疗床移位。
基于室内激光系统的位置内设置显示平面内最大差异在1.5mm以内。射程可重复性(标准差)小于0.14mm。设置和束流误差对结果没有显著影响,除了10mm的垂直位移会导致射程计算出现误差。
考虑到不同的日常设置和束流误差,已证明使用所提出的系统每日确定射程具有可重复性。