Colloca Giuseppe, Tagliaferri Luca, Capua Beatrice Di, Gambacorta Maria Antonietta, Lanzotti Vito, Bellieni Andrea, Monfardini Silvio, Balducci Lodovico, Bernabei Roberto, Cho William C, Valentini Vincenzo
1Fondazione Policlinico Universitario Agostino Gemelli IRCCS, UOC di Radioterapia, Dipartimento di Scienze Radiologiche, Radioterapiche ed Ematologiche, Roma, Italy.
3GIOGER Gruppo italiano di Oncologia Geriatrica, Italy.
Aging Dis. 2020 May 9;11(3):649-657. doi: 10.14336/AD.2019.0616. eCollection 2020 May.
Radiation oncology has the potential to be an excellent option for the frail elderly cancer patients because of its limited systemic toxicities. It can be effective for curative, prophylactic, disease control or palliative purposes. Currently about 60% of all cancer patients undergoing active treatment at some point receive radiation treatment. However, though widely used, there are limited clinical trials strictly designed for the elderly. This paper will review the key points in the assessment and treatment of elderly cancer patient including quality of life, active life expectancy, cognitive performance, frailty, sarcopenia and how the new technologies can help to reach the key goal of maintaining autonomy and independence for the elderly cancer patient.
由于全身毒性有限，放射肿瘤学对于体弱的老年癌症患者而言有可能成为一个极佳的选择。它对于根治性、预防性、疾病控制或姑息性治疗目的均可能有效。目前，所有正在接受积极治疗的癌症患者中，约有60%在某个阶段会接受放射治疗。然而，尽管放射治疗被广泛使用，但专门针对老年人设计的严格临床试验却很有限。本文将综述老年癌症患者评估与治疗中的要点，包括生活质量、预期活跃寿命、认知表现、虚弱、肌肉减少症，以及新技术如何有助于实现维持老年癌症患者自主性和独立性这一关键目标。
