INSERM U1028, CNRS UMR5292, PSYR2 Team, Lyon Neuroscience Research Center, Université Claude Bernard, Lyon 1, Lyon, France; Centre Hospitalier Le Vinatier, Bron, France.
Centre Hospitalier Le Vinatier, Bron, France.
Neurosci Biobehav Rev. 2018 May;88:98-105. doi: 10.1016/j.neubiorev.2018.03.004. Epub 2018 Mar 13.
Growing evidence has suggested that mindfulness-based interventions (MBIs) could have beneficial effects on the acute phase of depression and on the prevention of depressive relapse or recurrence. Despite growing clinical interest, the effects of MBIs on brain functioning in patients with MDD remain unclear. The aim of this systematic review was to assess the changes in brain functioning associated with MBIs in patients with MDD. A systematic search was conducted, and of the 56 articles found, 8 were eligible. MBIs have modulatory effects on several brain regions implicated in the pathophysiology of MDD, such as the prefrontal cortex, the basal ganglia, the anterior and posterior cingulate cortices, and the parietal cortex. These regions have been implicated in self-awareness, attention and emotion regulation. Some of these findings were consistent with the effects of MBIs observed in healthy subjects and patients with other psychiatric disorders, especially enhanced activity in the frontal and subcortical regions related to the improved somatosensory awareness. Further studies are needed to elucidate the mechanisms of MBIs in MDD.
越来越多的证据表明，正念干预（MBI）可能对抑郁症的急性期和预防抑郁复发或再发有有益的影响。尽管越来越受到临床关注，但 MBI 对 MDD 患者大脑功能的影响仍不清楚。本系统评价的目的是评估 MBI 对 MDD 患者大脑功能的变化。进行了系统搜索，在发现的 56 篇文章中，有 8 篇符合条件。MBI 对与 MDD 病理生理学相关的几个大脑区域有调节作用，如前额叶皮层、基底神经节、前后扣带皮层和顶叶皮层。这些区域与自我意识、注意力和情绪调节有关。其中一些发现与在健康受试者和其他精神障碍患者中观察到的 MBI 效应一致，特别是与改善躯体感觉意识相关的额皮质和皮质下区域的活动增强。需要进一步的研究来阐明 MBI 在 MDD 中的作用机制。
