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渥太华3DY和简易精神状态检查表检测急诊科老年患者认知功能障碍的诊断准确性

Diagnostic accuracy of the Ottawa 3DY and Short Blessed Test to detect cognitive dysfunction in geriatric patients presenting to the emergency department.

作者信息

Barbic David, Kim Brian, Salehmohamed Qadeem, Kemplin Kate, Carpenter Christopher R, Barbic Skye Pamela

机构信息

Department of Emergency Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

出版信息

BMJ Open. 2018 Mar 16;8(3):e019652. doi: 10.1136/bmjopen-2017-019652.

Abstract

OBJECTIVES

Cognitive dysfunction (CD) is a common finding in geriatric patients presenting to the emergency department (ED). Our primary objective was to determine the diagnostic accuracy of the Ottawa 3DY (O3DY) and Short Blessed Test (SBT) as screening tools for the detection of CD in the ED. Our secondary objective was to estimate the inter-rater reliability of these instruments.

METHODS

We conducted a prospective cross-sectional comparative study at an inner-city academic medical centre (annual ED visit census 86 000). Patients aged 75 years or greater were evaluated for inclusion, 163 were screened, 150 were deemed eligible and 117 were enrolled. The research team completed the O3DY, SBT and Mini-Mental State Exam (MMSE) for each participant. Descriptive statistics were calculated. Sensitivity and specificity of the O3DY and SBT were calculated in STATA V.11.2 using the MMSE as our criterion standard.

RESULTS

We enrolled 117 patients from June to November 2016. The median ED length of stay at the time of completion of all tests was 1:40 (IQR 1:34-1:46). The sensitivity of the O3DY was 71.4% (95% CI 47.8 to 95.1), and specificity was 56.3% (46.7-65.9). Sensitivity of the SBT was 85.7% (67.4-99.9) and specificity was 58.3% (48.7-67.8). The receiver operating characteristic area under the curve was calculated for the O3DY (0.51; 95% CI 0.42 to 0.61) and SBT (0.52; 95% CI 0.43 to 0.61) relative to the MMSE. Inter-rater reliability for the O3DY (k=0.64) and SBT (k=0.63) were good.

CONCLUSION

In a cohort of geriatric patients presenting to an inner-city academic ED, the O3DY and SBT tools demonstrate moderate sensitivity and specificity for the detection of CD. Inter-rater reliability for the O3DY and SBT were good. Future research on this topic should attempt to derive and validate ED-specific screening tools, which will hopefully result in more robust likelihood ratios for the screening of CD in ED geriatric patients.

摘要

目的

认知功能障碍(CD)在前往急诊科(ED)就诊的老年患者中很常见。我们的主要目的是确定渥太华3DY(O3DY)和简易精神状态检查表(SBT)作为急诊科检测CD的筛查工具的诊断准确性。我们的次要目的是评估这些工具在不同评估者之间的可靠性。

方法

我们在一家市中心的学术医疗中心进行了一项前瞻性横断面比较研究(急诊科年就诊人数普查为86000人)。对75岁及以上的患者进行纳入评估,163人接受了筛查,150人被认为符合条件,117人被纳入研究。研究团队为每位参与者完成了O3DY、SBT和简易精神状态检查(MMSE)。计算了描述性统计数据。在STATA V.11.2中,以MMSE作为标准,计算了O3DY和SBT的敏感性和特异性。

结果

我们在2016年6月至11月期间纳入了117名患者。完成所有测试时,急诊科的中位住院时间为1:40(四分位距1:34 - 1:46)。O3DY的敏感性为71.4%(95%可信区间47.8至95.1),特异性为56.3%(46.7 - 65.9)。SBT的敏感性为85.7%(67.4 - 99.9),特异性为58.3%(48.7 - 67.8)。相对于MMSE,计算了O3DY(曲线下面积0.51;95%可信区间0.42至0.61)和SBT(曲线下面积0.52;95%可信区间0.43至0.61)的受试者工作特征曲线下面积。O3DY(k = 0.64)和SBT(k = 0.63)在不同评估者之间的可靠性良好。

结论

在一组前往市中心学术急诊科就诊的老年患者中,O3DY和SBT工具在检测CD方面表现出中等的敏感性和特异性。O3DY和SBT在不同评估者之间的可靠性良好。关于这个主题的未来研究应尝试推导和验证急诊科专用筛查工具,这有望为急诊科老年患者筛查CD得出更可靠的似然比。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fb0/5857706/cc9bc997cc31/bmjopen-2017-019652f01.jpg

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