Sohrabi Maryam, Alahgholi-Hajibehzad Mahdi, Gholami Mahmoodian Zahra, Hosseini Siyar Sayed Ali, Zamani Alireza
Department of Anatomy, Hamadan University of Medical Sciences, Hamadan, Iran.
Iran J Immunol. 2018 Mar;15(1):38-46.
Studies have indicated that extraweight and obesity induce chronic inflammation, which can lead to other diseases such as cancers.
To evaluate the effects of two weight-lowering and anti-inflammatory agents including cinnamon, and turmeric, on serum levels of interleukin-17 (IL-17) as a pro-inflammatory cytokine.
In this study, 64 rats were designated in eight groups. The control group received normal diet. The other groups were fed with normal diet plus high cinnamon (3 mg/ml), high turmeric (3 mg/ml), high-fructose solution (30%), fructose solution with low (0.15 mg/ml) and high doses (3 mg/ml) of cinnamon and turmeric three times per week. The serum level of IL-17F was measured by enzyme-linked immunosorbent assay (ELISA).
High fructose consumption led to an increase in the weight and serum level of IL-17. While, feeding with cinnamon and turmeric caused to decline weight but, surprisingly increased IL-17F levels.
Although, some studies have showed that cinnamon and turmeric supplementation decreased IL-17F under the standard diet, in the presence of high fructose diet and extraweight their effects were reversed and caused an increase in serum level of IL-17F.
研究表明，超重和肥胖会引发慢性炎症，进而可能导致癌症等其他疾病。
评估肉桂和姜黄这两种具有减肥和抗炎作用的药物对促炎细胞因子白细胞介素-17（IL-17）血清水平的影响。
本研究将64只大鼠分为八组。对照组给予正常饮食。其他组每周三次喂食正常饮食加高剂量肉桂（3毫克/毫升）、高剂量姜黄（3毫克/毫升）、高糖溶液（30%）、低剂量（0.15毫克/毫升）和高剂量（3毫克/毫升）肉桂及姜黄的糖溶液。采用酶联免疫吸附测定法（ELISA）检测IL-17F的血清水平。
高糖饮食导致体重增加和IL-17血清水平升高。而喂食肉桂和姜黄导致体重下降，但令人惊讶的是，IL-17F水平升高。
尽管一些研究表明，在标准饮食情况下补充肉桂和姜黄可降低IL-17F水平，但在高糖饮食和超重情况下，其作用相反，导致IL-17F血清水平升高。
