Department of Informatics, University of Oslo, Oslo, Norway.
Department of Neurosurgery, Oslo University Hospital - Rikshospitalet, Oslo, Norway.
Sci Rep. 2018 Mar 16;8(1):4714. doi: 10.1038/s41598-018-23142-7.
This study explored the hypothesis that the central aortic blood pressure (BP) waveform may be used for non-invasive estimation of the intracranial pressure (ICP) waveform. Simultaneous invasive ICP and radial artery BP waveforms were measured in 29 individuals with idiopathic normal pressure hydrocephalus (iNPH). The central aortic BP waveforms were estimated from the radial artery BP waveforms using the SphygmoCor system. For each individual, a transfer function estimate between the central aortic BP and the invasive ICP waveforms was found (Intra-patient approach). Thereafter, the transfer function estimate that gave the best fit was chosen and applied to the other individuals (Inter-patient approach). To validate the results, ICP waveform parameters were calculated for the estimates and the measured golden standard. For the Intra-patient approach, the mean absolute difference in invasive versus non-invasive mean ICP wave amplitude was 1.9 ± 1.0 mmHg among the 29 individuals. Correspondingly, the Inter-patient approach resulted in a mean absolute difference of 1.6 ± 1.0 mmHg for the 29 individuals. This method gave a fairly good estimate of the wave for about a third of the individuals, but the variability is quite large. This approach is therefore not a reliable method for use in clinical patient management.
本研究旨在探讨如下假设，即主动脉中心血压（BP）波形可用于对颅内压（ICP）波形进行无创估计。对 29 名特发性正常压力脑积水（iNPH）患者进行了同时有创性 ICP 和桡动脉 BP 波形的测量。使用 SphygmoCor 系统从桡动脉 BP 波形来估计主动脉中心 BP 波形。对于每一个体，都在主动脉中心 BP 和有创性 ICP 波形之间找到了传递函数估计值（个体内方法）。此后，选择给出最佳拟合的传递函数估计值并将其应用于其他个体（个体间方法）。为了验证结果，为估计值和测量的金标准计算了 ICP 波形参数。对于个体内方法，29 名个体中，侵袭性与非侵袭性平均 ICP 波幅度之间的平均绝对差值为 1.9±1.0mmHg。相应地，对于 29 名个体，个体间方法导致平均绝对差值为 1.6±1.0mmHg。这种方法对于大约三分之一的个体来说可以相当好地估计波，但变异性相当大。因此，该方法不是用于临床患者管理的可靠方法。
