GENUD (Growth, Exercise, NUtrition and Development) Research Group, Faculty of Health Sciences, University of Zaragoza, Spain Edificio del SAI, C/Pedro Cerbuna s/n, 50009, Saragossa, Spain.
Instituto Agroalimentario de Aragón (IA2), Saragossa, Spain.
Int J Public Health. 2018 May;63(4):501-512. doi: 10.1007/s00038-018-1090-x. Epub 2018 Mar 16.
To explore early life risk factors of overweight/obesity at age 6 years and their cumulative effects on overweight/obesity at ages 2, 4 and 6 years.
Altogether 1031 Spanish children were evaluated at birth and during a 6-year follow-up. Early life risk factors included: parental overweight/obesity, parental origin/ethnicity, maternal smoking during pregnancy, gestational weight gain, gestational age, birth weight, caesarean section, breastfeeding practices and rapid infant weight gain collected via hospital records. Cumulative effects were assessed by adding up those early risk factors that significantly increased the risk of overweight/obesity. We conducted binary logistic regression models.
Rapid infant weight gain (OR 2.29, 99% CI 1.54-3.42), maternal overweight/obesity (OR 1.93, 99% CI 1.27-2.92), paternal overweight/obesity (OR 2.17, 99% CI 1.44-3.28), Latin American/Roma origin (OR 3.20, 99% CI 1.60-6.39) and smoking during pregnancy (OR 1.61, 99% CI 1.01-2.59) remained significant after adjusting for confounders. A higher number of early life risk factors accumulated was associated with overweight/obesity at age 6 years but not at age 2 and 4 years.
Rapid infant weight gain, parental overweight/obesity, maternal smoking and origin/ethnicity predict childhood overweight/obesity and present cumulative effects. Monitoring children with rapid weight gain and supporting a healthy parental weight are important for childhood obesity prevention.
探究 6 岁时超重/肥胖的早期生命风险因素及其对 2、4 和 6 岁时超重/肥胖的累积影响。
共有 1031 名西班牙儿童在出生时和 6 年随访期间接受了评估。早期生命风险因素包括：父母超重/肥胖、父母原籍/种族、母亲怀孕期间吸烟、孕期体重增加、胎龄、出生体重、剖宫产、母乳喂养实践和婴儿快速增重，这些数据均通过医院记录收集。累积效应通过累加那些显著增加超重/肥胖风险的早期风险因素来评估。我们进行了二元逻辑回归模型分析。
婴儿快速增重（OR 2.29，99%CI 1.54-3.42）、母亲超重/肥胖（OR 1.93，99%CI 1.27-2.92）、父亲超重/肥胖（OR 2.17，99%CI 1.44-3.28）、拉丁裔/罗姆人原籍（OR 3.20，99%CI 1.60-6.39）和怀孕期间吸烟（OR 1.61，99%CI 1.01-2.59）在调整混杂因素后仍具有显著性。累积的早期生命风险因素数量越多，与 6 岁时超重/肥胖相关，但与 2 岁和 4 岁时无关。
婴儿快速增重、父母超重/肥胖、母亲吸烟和原籍/种族预测儿童超重/肥胖，并呈现累积效应。监测体重快速增加的儿童并支持健康的父母体重对于预防儿童肥胖非常重要。
