The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China.
The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China.
Mater Sci Eng C Mater Biol Appl. 2018 Jun 1;87:120-127. doi: 10.1016/j.msec.2018.02.021. Epub 2018 Feb 28.
Cancer theranostics agents, such as gold nanorods, represent great potential in cancer therapy However, the big size and the low yield of the gold nanorods reported previously have limited their clinical translation. Therefore, it is significant to develop a new method to prepare the small gold nanorods (width <8 nm) at larger scale. In this report, a modified seedless method was proposed based on the effect of precursor concentration assisted synthesis of high quality small gold nanorods at large scale. The obtained small gold nanorods exhibit high quality and dimension of (18 ± 5 nm) × (5 ± 1 nm). After modified with biological compatibility reagents, the small gold nanorods behave excellent photoacoustic imaging and photo-thermal therapy ability. These results manifest that the obtained small gold nanorods not only realize the improvements of previously limitations, also are thus supposed to pave the way to cancer theranostics in clinic application.
癌症治疗剂，如金纳米棒，在癌症治疗方面具有巨大的潜力。然而，之前报道的金纳米棒尺寸较大且产量较低，限制了其临床转化。因此，开发一种新的方法来制备小尺寸（宽度<8nm）的金纳米棒具有重要意义。本研究基于前体浓度对小尺寸金纳米棒的辅助合成作用，提出了一种改良的无种子法，实现了高质量小尺寸金纳米棒的大规模制备。所制备的小尺寸金纳米棒具有优良的品质和尺寸（18±5nm）×（5±1nm）。经过生物相容性试剂修饰后，小尺寸金纳米棒表现出优异的光声成像和光热治疗能力。这些结果表明，所获得的小尺寸金纳米棒不仅实现了之前限制的改进，而且有望为癌症治疗在临床应用中铺平道路。
