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金纳米棒的制备、减毒及放射治疗应用。

Preparation, toxicity reduction and radiation therapy application of gold nanorods.

机构信息

Department of Radiation Oncology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.

Institute of Medical Engineering, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.

出版信息

J Nanobiotechnology. 2021 Dec 28;19(1):454. doi: 10.1186/s12951-021-01209-4.

DOI:10.1186/s12951-021-01209-4
PMID:34963479
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8715590/
Abstract

Gold nanorods (GNRs) have a broad application prospect in biomedical fields because of their unique properties and controllable surface modification. The element aurum (Au) with high atomic number (high-Z) render GNRs ideal radiosensitive materials for radiation therapy and computed tomography (CT) imaging. Besides, GNRs have the capability of efficiently converting light energy to heat in the near-infrared (NIR) region for photothermal therapy. Although there are more and more researches on GNRs for radiation therapy, how to improve their biocompatibility and how to efficiently utilize them for radiation therapy should be further studied. This review will focuse on the research progress regarding the preparation and toxicity reduction of GNRs, as well as GNRs-mediated radiation therapy.

摘要

金纳米棒（GNRs）由于其独特的性质和可控制的表面修饰，在生物医学领域有广泛的应用前景。高原子序数（高-Z）的元素金（Au）使 GNRs 成为放射治疗和计算机断层扫描（CT）成像的理想放射敏感性材料。此外，GNRs 具有在近红外（NIR）区域将光能高效转化为热的能力，用于光热治疗。尽管对于 GNRs 用于放射治疗的研究越来越多，但如何提高其生物相容性以及如何有效地将其用于放射治疗仍需进一步研究。这篇综述将重点介绍 GNRs 的制备和毒性降低以及 GNRs 介导的放射治疗方面的研究进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfea/8715590/e00fc0578e96/12951_2021_1209_Fig11_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfea/8715590/c0818b5f700e/12951_2021_1209_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfea/8715590/7f357dca6294/12951_2021_1209_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfea/8715590/93e199108784/12951_2021_1209_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfea/8715590/68772f87802e/12951_2021_1209_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfea/8715590/81802247e1d6/12951_2021_1209_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfea/8715590/524e1390cab8/12951_2021_1209_Fig9_HTML.jpg
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