Hu Lei, Wu Huo, Wan Xiao, Liu Liu, He Yiren, Zhu Liang, Liu Shaojun, Yao Hanhui, Zhu Zhiqiang
Department of General Surgery, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, Anhui, 230001, China.
Department of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230001, China.
Biochem Biophys Res Commun. 2018 Apr 30;499(1):52-58. doi: 10.1016/j.bbrc.2018.03.116. Epub 2018 Mar 19.
Increasing evidence reveals that microRNA contributes to the development and progression of gastric cancer (GC), but the roles of miR-585 in GC remain unclear. In this study, we confirmed that miR-585 was down-regulated in GC tissues and cell lines and that miR-585 expression was related to extent of invasion, TNM stage, lymph node invasion and poor prognosis. Our results showed that miR-585 inhibits the proliferation and migration of GC, and MAPK1 is a direct and functional target of miR-585. Our study sheds light on the role of miR-585 as a suppressor for tumor growth and metastasis and raises the intriguing possibility that miR-585 may serve as a new potential marker for monitoring and treating GC.
越来越多的证据表明，微小RNA促进胃癌（GC）的发展和进程，但miR-585在胃癌中的作用仍不清楚。在本研究中，我们证实miR-585在胃癌组织和细胞系中表达下调，且miR-585表达与侵袭范围、TNM分期、淋巴结侵袭及预后不良相关。我们的结果表明，miR-585抑制胃癌的增殖和迁移，且丝裂原活化蛋白激酶1（MAPK1）是miR-585直接的功能性靶点。我们的研究揭示了miR-585作为肿瘤生长和转移抑制因子的作用，并提出了miR-585可能作为监测和治疗胃癌的新潜在标志物这一有趣的可能性。
