de León H, Castañeda-Hernández G, Hong E
Life Sci. 1987 Jul 20;41(3):341-8. doi: 10.1016/0024-3205(87)90158-5.
The relationship between ANF activity and hypertension was determined by measuring ANF atrial content and vascular reactivity in two different models: spontaneous hypertensive rats (SHR) and renal hypertensive rats (RHR). Atrial extracts and aortic strips were prepared from hypertensive and normotensive animals. Relaxant activities of extracts, synthetic ANF and nitroglycerin were assayed on superfused aortic strips previously contracted by norepinephrine. ANF atrial content was statistically significantly lower in both models of hypertension, presumably by increased ANF release into the circulation which results in depletion of tissue storage sites. Vascular subsensitivity to ANF and nitroglycerin was found in both models of hypertension. Diminished ANF vascular reactivity in hypertension could be due to receptor down-regulation and/or to a decrease in the ability of cGMP to induce relaxation.
自发性高血压大鼠（SHR）和肾性高血压大鼠（RHR）中测量心房钠尿肽（ANF）的心房含量和血管反应性，确定了ANF活性与高血压之间的关系。从高血压和正常血压动物制备心房提取物和主动脉条。在预先用去甲肾上腺素收缩的灌流主动脉条上测定提取物、合成ANF和硝酸甘油的舒张活性。在两种高血压模型中，ANF的心房含量在统计学上均显著降低，推测是由于ANF释放到循环中增加，导致组织储存部位耗尽。在两种高血压模型中均发现血管对ANF和硝酸甘油的敏感性降低。高血压中ANF血管反应性降低可能是由于受体下调和/或cGMP诱导舒张能力的降低。
