INSERM U1016, team "Mucosal microbiota in chronic inflammatory diseases", CNRS UMR 8104, Université de Paris, Paris, France.
Microenvironment & Immunity Unit, Pasteur Institute, INSERM U1224, Paris, France.
Mucosal Immunol. 2021 Sep;14(5):1006-1016. doi: 10.1038/s41385-021-00383-w. Epub 2021 Mar 26.
During the last 20 years, a new field of research delineating the importance of the microbiota in health and diseases has emerged. Inappropriate host-microbiota interactions have been shown to trigger a wide range of chronic inflammatory diseases, and defining the exact mechanisms behind perturbations of such relationship, as well as ways by which these disturbances can lead to disease states, both remain to be fully elucidated. The mucosa-associated microbiota constitutes a recently studied microbial population closely linked with the promotion of chronic intestinal inflammation and associated disease states. This review will highlight seminal works that have brought into light the importance of the mucosa-associated microbiota in health and diseases, emphasizing the challenges and promises of expending the mucosal microbiology field of research.
在过去的 20 年中，一个新的研究领域已经出现，强调了微生物群在健康和疾病中的重要性。已经表明，宿主与微生物群之间的不当相互作用会引发广泛的慢性炎症性疾病，并且仍然需要充分阐明这种关系发生变化的确切机制，以及这些干扰如何导致疾病状态。黏膜相关微生物群是最近研究的微生物群体，与慢性肠道炎症和相关疾病状态的促进密切相关。这篇综述将强调一些开创性的工作，这些工作已经揭示了黏膜相关微生物群在健康和疾病中的重要性，强调了扩展黏膜微生物学研究领域的挑战和前景。
