Hansen Richard A, Hohmann Natalie, Maciejewski Matthew L, Domino Marisa E, Ray Neepa, Mahendraratnam Nirosha, Farley Joel F
Harrison School of Pharmacy, Auburn University.
Division of General Internal Medicine, Department of Medicine, Duke University Medical Center.
J Pharm Health Serv Res. 2018 Mar;9(1):13-20. doi: 10.1111/jphs.12201. Epub 2017 Nov 20.
Adults with schizophrenia and cardiometabolic conditions may be good candidates for co-management by primary care prescribers and specialists. Associated risks for discontinuity in medication management have not been well-studied. This study examines whether medication adherence, inpatient admissions, and emergency department (ED) visits vary by the number and types of prescribers seen by adults with schizophrenia and cardiometabolic conditions.
This study used a retrospective cohort of 4,223 adult Medicaid enrollees with schizophrenia and hypertension, hyperlipidemia, and/or diabetes from three states in 2009-2010. Logistic regression models were run on outcome variables reflecting medication adherence, ED utilization, and inpatient admissions as a function of the number and types of prescribers.
Increases in number of psychiatric specialists were associated with better antipsychotic adherence, but decreasing statin adherence. Increases in number of psychiatric specialists were also associated with a higher probability of inpatient admission and ED visits, while increases in number of primary care prescribers were associated with increases in the probability of ED visits.
Greater antipsychotic adherence for adults receiving prescriptions from multiple psychiatric specialists was counteracted by lower statin adherence and greater risk of ED and inpatient utilization. This may help inform optimal care models for these complex individuals.
患有精神分裂症和心脏代谢疾病的成年人可能是初级保健开方者和专科医生共同管理的合适人选。药物管理中断的相关风险尚未得到充分研究。本研究调查了患有精神分裂症和心脏代谢疾病的成年人的药物依从性、住院次数和急诊就诊次数是否因所看开方者的数量和类型而异。
本研究采用回顾性队列研究,对2009 - 2010年来自三个州的4223名患有精神分裂症和高血压、高脂血症和/或糖尿病的成年医疗补助参保者进行研究。对反映药物依从性、急诊利用情况和住院次数的结局变量进行逻辑回归模型分析,将其作为开方者数量和类型的函数。
精神科专科医生数量的增加与更好的抗精神病药物依从性相关,但他汀类药物依从性降低。精神科专科医生数量的增加还与住院和急诊就诊的更高可能性相关,而初级保健开方者数量的增加与急诊就诊可能性的增加相关。
从多个精神科专科医生处获得处方的成年人更高的抗精神病药物依从性被较低的他汀类药物依从性以及更高的急诊和住院利用风险所抵消。这可能有助于为这些复杂个体制定最佳护理模式提供信息。