广泛的应对策略在 COMBINE 研究中调节联合行为干预对酒精结果的影响:潜在类别中介分析的应用。

Broad Coping Repertoire Mediates the Effect of the Combined Behavioral Intervention on Alcohol Outcomes in the COMBINE Study: An Application of Latent Class Mediation.

机构信息

Department of Psychology, University of New Mexico, Albuquerque, New Mexico.

Department of Individual, Family and Community Education, University of New Mexico, Albuquerque, New Mexico.

出版信息

J Stud Alcohol Drugs. 2018 Mar;79(2):199-207. doi: 10.15288/jsad.2018.79.199.

Abstract

OBJECTIVE

Few studies have found support for coping as a mechanism of behavior change (MOBC) following coping skills training interventions for alcohol use disorder (AUD). One potential reason for null findings is heterogeneity in the patterns of coping skills acquired during treatment. This study sought to identify latent classes of coping and to test the latent class variable as a mediator of the effect of a combined behavioral intervention for AUD.

METHOD

Secondary analyses of data from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) Study (N = 1,124; mean age = 44.4 years; 69.1% male; 23.2% non-White), a multisite study of medication and behavioral treatments for individuals with AUD. Latent class mediation models were estimated to test whether patterns of alcohol-specific coping mediated the effect of combined behavioral intervention with medication management, as compared with medication management only, on drinking outcomes 12 months following treatment.

RESULTS

Three classes were identified, which differed in repertoire broadness, or the degree in which a wide range of different skills were used. Coping repertoire class was a significant mediator of the effect of the combined behavioral intervention on drinking outcomes. Receiving the combined behavioral intervention, in addition to medication management, predicted a greater likelihood of expected classification in the broad coping repertoire class, which in turn was associated with significant improvements in drinking outcomes.

CONCLUSIONS

Using the novel methodological approach of latent class mediation, this study identified coping repertoire as a significant mediator of behavioral intervention efficacy for AUD. Future work examining heterogeneity in mediators and outcomes may help refine AUD treatment to be maximally effective.

摘要

目的

在针对酒精使用障碍(AUD)的应对技能训练干预措施之后,很少有研究发现应对作为行为改变机制(MOBC)的支持。造成阴性结果的一个潜在原因是治疗过程中获得的应对技能模式存在异质性。本研究旨在确定应对的潜在类别,并检验潜在类别变量作为 AUD 联合行为干预效果的中介变量。

方法

对来自药物联合治疗和酒精依赖行为干预(COMBINE)研究(N=1124;平均年龄 44.4 岁;69.1%为男性;23.2%为非白人)的数据进行二次分析,这是一项针对药物和行为治疗酒精依赖患者的多地点研究。估计潜在类别中介模型,以检验在治疗后 12 个月,特定于酒精的应对模式是否作为联合行为干预与药物管理相比,对饮酒结果的影响的中介变量。

结果

确定了三种类别,它们在应对技能的广度或使用范围广泛度方面存在差异。应对范围类别是联合行为干预对饮酒结果的影响的重要中介变量。除药物管理外,还接受联合行为干预,与预期的广泛应对范围类别分类的可能性更大相关,而这反过来又与饮酒结果的显著改善相关。

结论

使用潜在类别中介的新方法学方法,本研究确定了应对范围作为 AUD 行为干预效果的重要中介变量。未来研究检验中介变量和结果的异质性可能有助于将 AUD 治疗精确到最大限度地提高效果。

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