Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign.
Rehabil Psychol. 2018 Feb;63(1):111-120. doi: 10.1037/rep0000202.
There is evidence that motor and cognitive impairments often co-occur in multiple sclerosis (MS). There is little research on influences of cognitive-motor coupling, particularly depressive symptoms. This study examined depressive symptoms as a moderator and/or confounder of cognitive-motor coupling in persons with MS.
The sample included 131 persons with MS who were allocated into elevated and nonelevated depressive symptom groups based on a cutoff score of 8 on the Hospital Anxiety Depression Scale. We assessed lower (i.e., 6-Minute Walk Test, Timed 25-Foot Walk Test) and upper (i.e., Nine-Hole Peg Test) body function as well as cognition (i.e., the Symbol Digit Modalities Test, CA Verbal Learning Test, and Brief Visuospatial Memory Test) in a research laboratory. Depressive symptomology was investigated as a moderator and/or confounder of cognitive-motor coupling using correlation and linear regression analyses.
Upper and lower body function, but not cognition, differed significantly between depressive symptoms groups (p < .05). Scores on the motor and cognitive tests were uniformly correlated between depressive symptom groups. Depressive symptom category did not confound the coupling between motor and cognitive functions, and explained additional, but minimal, variation in the lower body motor function scores (p < .05).
Strong coupling between motor function and cognitive processing speed in MS appeared to be consistent between depressive symptom groups. Elevated depressive symptoms might influence motor functioning more strongly than cognitive functioning in MS. (PsycINFO Database Record
有证据表明，运动和认知障碍在多发性硬化症（MS）中经常同时发生。关于认知-运动耦合的影响，特别是抑郁症状的研究很少。本研究探讨了抑郁症状作为多发性硬化症患者认知-运动耦合的调节因素和/或混杂因素。
该样本包括 131 名多发性硬化症患者，根据医院焦虑抑郁量表（Hospital Anxiety Depression Scale）上 8 分的截定点，将他们分为抑郁症状升高和无升高的两组。我们在研究实验室中评估了较低的身体功能（即 6 分钟步行测试、定时 25 英尺步行测试）和较高的身体功能（即 9 孔钉测试）以及认知功能（即符号数字模态测试、CA 言语学习测试和简短视觉空间记忆测试）。使用相关和线性回归分析，研究抑郁症状作为认知-运动耦合的调节因素和/或混杂因素。
在抑郁症状组之间，上半身和下半身的功能（但不是认知功能）存在显著差异（p<.05）。在抑郁症状组之间，运动和认知测试的分数均匀相关。运动和认知功能之间的耦合不受抑郁症状类别的干扰，并且解释了下半身运动功能评分的额外但最小的变化（p<.05）。
在多发性硬化症中，运动功能和认知处理速度之间的强耦合似乎在抑郁症状组之间是一致的。在多发性硬化症中，升高的抑郁症状可能比认知功能更强烈地影响运动功能。
