Cognitive-Motor Coupling in Multiple Sclerosis: Do Chronological Age and Physical Activity Matter?

: People with multiple sclerosis (MS) often demonstrate both cognitive and physical dysfunctions, particularly with greater age and lower physical activity levels, and there is evidence of a relationship between these outcomes (i.e., cognitive-motor coupling) in MS. To date, little is known about cognitive-motor coupling when controlling for chronological age and levels of physical activity. : We examined cognitive-motor coupling in people with MS while accounting for chronological age and physical activity. : The sample included 290 people with MS between the ages of 22 and 77 years. Participants underwent the Symbol Digit Modalities Test (SDMT) for cognitive processing speed and the California Verbal Learning and Memory Test-Second Edition (CVLT-II) for verbal learning and memory. Participants completed the 6-Minute Walk and the Timed 25-Foot Walk tests for walking endurance and speed, respectively. Participants wore an accelerometer for a 7-day period to measure moderate-to-vigorous physical activity (MVPA). : The bivariate correlation analyses indicated that cognitive function had moderate-to-strong associations with motor function (range of between 0.433 and 0.459). The linear regression analyses indicated cognitive-motor coupling between SDMT and motor function (with a range of β between 0.139 and 0.145) when controlling for demographic and clinical characteristics. The regression analyses further indicated that the CVLT-II was associated with motor function (with a range of β between 0.125 and 0.135) when controlling for demographic and clinical characteristics. When age and MVPA were entered into the regression analyses, SDMT was still associated with the motor function of individuals (β = 0.119), and CVLT-II was still associated with the motor function of individuals (with a range of β between 0.115 and 0.124). Cognitive-motor coupling is present in people with MS independent of chronological age and levels of physical activity. This warrants further investigation of the underlying mechanism and potential approaches for the management of co-occurring MS-related dysfunction.