一种来自土曲霉H010真菌的新型抗炎半萜类化合物。
A new anti-inflammatory meroterpenoid from the fungus Aspergillus terreus H010.
作者信息
Liu Zhaoming, Liu Hongju, Chen Yan, She Zhigang
机构信息
a School of Chemistry , Sun Yat-sen University , Guangdong , China.
b School of Pharmacy , Guangdong Medical University , Guangdong , China.
出版信息
Nat Prod Res. 2018 Nov;32(22):2652-2656. doi: 10.1080/14786419.2017.1375924. Epub 2017 Sep 13.
An unusual austinoid, 1,2-dehydro-terredehydroaustin (1), together with two known meroterpenoids (2 and 3), were isolated from the mangrove endophytic fungus Aspergillus terreus. The structures were elucidated on the basis of spectroscopic data, X-ray diffraction and ECD calculations. The anti-inflammatory activity was assayed and compound 1 exhibited weak inhibition effect against the production of nitric oxide (NO) in lipopolysaccharide (LPS)-induced RAW 246.7 mouse macrophages with an IC value of 42.3 μM.
从红树林内生真菌土曲霉中分离出一种不寻常的奥司汀类化合物1,2-脱氢-terredehydroaustin（1），以及两种已知的半萜类化合物（2和3）。通过光谱数据、X射线衍射和ECD计算确定了其结构。测定了抗炎活性，化合物1对脂多糖（LPS）诱导的RAW 246.7小鼠巨噬细胞中一氧化氮（NO）的产生表现出较弱的抑制作用，IC值为42.3 μM。
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