Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China; Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China; Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China.
Fitoterapia. 2018 Nov;131:50-54. doi: 10.1016/j.fitote.2018.10.011. Epub 2018 Oct 9.
Four new aromatic butenolides, asperimides A-D (1-4), together with a known analogue, butyrolactone I (5), were isolated from solid cultures of a tropical endophytic fungus Aspergillus terreus. The structures of these compounds were elucidated on the basis of spectroscopic methods and electronic circular dichroism calculations. Compounds 1-4 represent the first examples of butenolides with a maleimide core isolated from Aspergillus sp. Inhibitory effects of the isolated compounds on nitric oxide production were investigated in lipopolysaccaride (LPS)-mediated RAW 264.7 cells. Compounds 3 and 4 exhibited potent anti-inflammatory with IC values of 0.78 ± 0.06 and 1.26 ± 0.11 μM, respectively.
四种新的芳香丁烯内酯，asperimides A-D（1-4），与一种已知的类似物，butyrolactone I（5），从热带内生真菌 Aspergillus terreus 的固体培养物中分离出来。这些化合物的结构是根据光谱方法和电子圆二色性计算确定的。化合物 1-4 代表了从 Aspergillus sp. 中分离出的具有马来酰亚胺核心的丁烯内酯的第一个例子。对分离得到的化合物在脂多糖（LPS）介导的 RAW 264.7 细胞中对一氧化氮产生的抑制作用进行了研究。化合物 3 和 4 表现出较强的抗炎活性，IC 值分别为 0.78±0.06 和 1.26±0.11 μM。
