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真菌萘醌类化合物；药物发现有潜力的代谢产物：结构、生物合成、来源和药理学潜力。

Fungal Naphthalenones; Promising Metabolites for Drug Discovery: Structures, Biosynthesis, Sources, and Pharmacological Potential.

机构信息

Department of Chemistry, Preparatory Year Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia.

Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

出版信息

Toxins (Basel). 2022 Feb 19;14(2):154. doi: 10.3390/toxins14020154.

DOI:10.3390/toxins14020154
PMID:35202181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8879409/
Abstract

Fungi are well-known for their abundant supply of metabolites with unrivaled structure and promising bioactivities. Naphthalenones are among these fungal metabolites, that are biosynthesized through the 1,8-dihydroxy-naphthalene polyketide pathway. They revealed a wide spectrum of bioactivities, including phytotoxic, neuro-protective, cytotoxic, antiviral, nematocidal, antimycobacterial, antimalarial, antimicrobial, and anti-inflammatory. The current review emphasizes the reported naphthalenone derivatives produced by various fungal species, including their sources, structures, biosynthesis, and bioactivities in the period from 1972 to 2021. Overall, more than 167 references with 159 metabolites are listed.

摘要

真菌以其丰富的代谢产物而闻名，这些代谢产物具有无与伦比的结构和有前途的生物活性。萘醌类化合物就是这些真菌代谢产物之一，它们是通过 1,8-二羟基萘聚酮途径生物合成的。它们表现出广泛的生物活性，包括植物毒性、神经保护、细胞毒性、抗病毒、杀线虫、抗分枝杆菌、抗疟疾、抗菌和抗炎。本综述重点介绍了 1972 年至 2021 年期间各种真菌物种产生的报道的萘醌衍生物，包括它们的来源、结构、生物合成和生物活性。总的来说，列出了超过 167 篇参考文献和 159 种代谢产物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/d384d986ca40/toxins-14-00154-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/cedfc0840756/toxins-14-00154-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/4a2e40466477/toxins-14-00154-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/a5546cded3f9/toxins-14-00154-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/221ff3640038/toxins-14-00154-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/300a1d64c4d4/toxins-14-00154-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/e3296a6b525d/toxins-14-00154-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/d384d986ca40/toxins-14-00154-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/31dcb21335f7/toxins-14-00154-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/f1f05280f5f7/toxins-14-00154-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/eed1ba40ed39/toxins-14-00154-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/2e1635f4a3eb/toxins-14-00154-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/e4eb37b39fa9/toxins-14-00154-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/8d49302a81a1/toxins-14-00154-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/aed70b73fc0b/toxins-14-00154-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/cedfc0840756/toxins-14-00154-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/4a2e40466477/toxins-14-00154-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/a5546cded3f9/toxins-14-00154-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/221ff3640038/toxins-14-00154-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/300a1d64c4d4/toxins-14-00154-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/e3296a6b525d/toxins-14-00154-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fcf/8879409/d384d986ca40/toxins-14-00154-g011.jpg

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