植物挥发油和甲醇提取物的化学成分及抗癌、抗菌和抗氧化活性研究。
Chemical composition and anticancer, antimicrobial and antioxidant activities of essential oil and methanol extract from .
机构信息
a Institute of Chemical Sciences , University of Peshawar , Peshawar , Pakistan.
b H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences , University of Karachi , Karachi , Pakistan.
出版信息
Nat Prod Res. 2019 Sep;33(17):2554-2559. doi: 10.1080/14786419.2018.1452009. Epub 2018 Mar 19.
Chemical composition, antioxidant, anticancer, and antimacrobial activities of essential oil obtained from leaves of has been evaluated here for the first time. GC/MS analysis reveals the presence of Palmitoleic Acid (28.35%) and Palmitic acid, (25. 37%) as their methyl ester as major components. The essential oil showed significant DPPH radical scavenging activity (94.907 ± 0.1089% and 94.003 ± 0.0749%) at concentration (100 and 80) μg/mL respectively. The oil showed promising activity against , while showed weak activity against (Hela and 3T3) cell lines. The crude extract / fractions of (leaves) showed significant antioxidant activity at dose (100 and 80) μg/mL. Futhermore the crude showed significant activity against (MCF-7 and MDA-MB-231) cell lines with IC (20.5138 ± 0.933 and 25.1728 ± 0.9176) μg/mL respectively, and chloroform fraction showed good activity against (MCF-7 and MDA-MB-231) cell lines with IC (31.154 ± 0.965 and 42.269 ± 2.1045) μg/mL.
首次评估了 叶片精油的化学成分、抗氧化、抗癌和抗菌活性。GC/MS 分析表明，主要成分是棕榈酸（28.35%）和棕榈酸甲酯（25.37%）。该精油在浓度（100 和 80）μg/mL 时对 DPPH 自由基清除活性分别显示出显著的效果（94.907±0.1089%和 94.003±0.0749%）。该油对 表现出良好的活性，而对 （Hela 和 3T3）细胞系表现出较弱的活性。粗提物/（叶）各馏分在剂量（100 和 80）μg/mL 时表现出显著的抗氧化活性。此外，粗提取物对 MCF-7 和 MDA-MB-231 细胞系表现出显著的活性，IC（20.5138±0.933 和 25.1728±0.9176）μg/mL，而氯仿馏分对 MCF-7 和 MDA-MB-231 细胞系表现出良好的活性，IC（31.154±0.965 和 42.269±2.1045）μg/mL。
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