Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha 410013, China.
Department of Medical Microbiology, Immunology & Cell Biology, Simmons Cancer Institute, Southern Illinois University School of Medicine, 913N. Rutledge Street, Springfield, IL 62794, USA.
Acta Biochim Biophys Sin (Shanghai). 2018 May 1;50(5):433-439. doi: 10.1093/abbs/gmy022.
In order to maintain integrity of the genome, eukaryotic cells develop a complex DNA damage/repair response network, which can induce cell cycle arrest, apoptosis, or DNA repair. Chemo- and radiation therapies, which act primarily through the induction of DNA damage, are the most commonly used therapies for cancer. Impairment in the DNA damage response and repair system that protect cells from persistent DNA damage can affect the therapeutic efficacy of cancer. To date, accumulating evidence has suggested that long non-coding RNAs (lncRNAs) are involved in the regulation of the DNA damage/repair network. LncRNAs have been demonstrated to be master regulators of the genome at the transcriptional and post-transcriptional levels and play a key role in many physiological and pathological processes of cells. In this review, we will discuss the function of lncRNAs in regulating the cellular response to DNA damage.
为了维护基因组的完整性，真核细胞会发展出一套复杂的 DNA 损伤/修复反应网络，该网络可诱导细胞周期停滞、细胞凋亡或 DNA 修复。通过诱导 DNA 损伤起主要作用的化学疗法和放射疗法是癌症最常用的治疗方法。保护细胞免受持续 DNA 损伤的 DNA 损伤反应和修复系统的损伤可能会影响癌症的治疗效果。迄今为止，越来越多的证据表明，长非编码 RNA（lncRNA）参与了 DNA 损伤/修复网络的调控。lncRNA 已被证明是转录和转录后水平上基因组的主要调控因子，并在细胞的许多生理和病理过程中发挥关键作用。在这篇综述中，我们将讨论 lncRNA 在调节细胞对 DNA 损伤的反应中的功能。
