Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Mol Biol Rep. 2024 Feb 17;51(1):308. doi: 10.1007/s11033-024-09288-w.
The DNA damage response (DDR) is a crucial cellular signaling pathway activated in response to DNA damage, including damage caused by chemotherapy. Chemoresistance, which refers to the resistance of cancer cells to the effects of chemotherapy, poses a significant challenge in cancer treatment. Understanding the relationship between DDR and chemoresistance is vital for devising strategies to overcome this resistance and improve treatment outcomes. Long non-coding RNAs (lncRNAs) are a class of RNA molecules that do not code for proteins but play important roles in various biological processes, including cancer development and chemoresistance. RNA-binding proteins (RBPs) are a group of proteins that bind to RNA molecules and regulate their functions. The interaction between lncRNAs and RBPs has been found to regulate gene expression at the post-transcriptional level, thereby influencing various cellular processes, including DDR signaling pathways. Multiple studies have demonstrated that lncRNAs can interact with RBPs to modulate the expression of genes involved in cancer chemoresistance by impacting DDR signaling pathways. Conversely, RBPs can regulate the expression and function of lncRNAs involved in DDR. Exploring these interactions can provide valuable insights for the development of innovative therapeutic approaches to overcome chemoresistance in cancer patients. This review article aims to summarize recent research on the interaction between lncRNAs and RBPs during cancer chemotherapy, with a specific focus on DDR pathways.
DNA 损伤反应（DDR）是一种重要的细胞信号通路，可被激活以应对 DNA 损伤，包括化疗引起的损伤。化疗耐药性是指癌细胞对化疗药物作用的抵抗，这是癌症治疗中的一个重大挑战。了解 DDR 与化疗耐药性之间的关系对于制定克服这种耐药性的策略以及改善治疗效果至关重要。长链非编码 RNA（lncRNA）是一类不编码蛋白质但在各种生物学过程中发挥重要作用的 RNA 分子，包括癌症的发生和化疗耐药性。RNA 结合蛋白（RBP）是一组与 RNA 分子结合并调节其功能的蛋白质。已经发现 lncRNA 与 RBPs 之间的相互作用可以通过影响 DDR 信号通路来调节转录后水平的基因表达，从而影响各种细胞过程。多项研究表明，lncRNA 可以通过影响 DDR 信号通路与 RBPs 相互作用来调节参与癌症化疗耐药性的基因的表达。相反，RBPs 可以调节参与 DDR 的 lncRNA 的表达和功能。探索这些相互作用可以为开发创新的治疗方法以克服癌症患者的化疗耐药性提供有价值的见解。本文旨在总结最近关于 lncRNA 和 RBPs 在癌症化疗过程中相互作用的研究进展，特别是在 DDR 通路方面。
