Steno Diabetes Center Copenhagen, Niels Steensens vej 2-4, 2820 Gentofte, Denmark.
Steno Diabetes Center Copenhagen, Niels Steensens vej 2-4, 2820 Gentofte, Denmark; National Institute of Public Health, University of Southern Denmark, Øster Farimagsgade 5A, 1353 Copenhagen K, Denmark.
Environ Res. 2018 Jul;164:310-315. doi: 10.1016/j.envres.2018.03.003. Epub 2018 Mar 20.
Studies have found mercury to be associated with cardiovascular disease (CVD), however, primarily in populations with low exposure. The highest levels, and variations in the levels, of whole blood mercury (WBM) worldwide have been found in Greenland. We prospectively assessed the association between WBM and the risk of developing CVD in the Greenlandic population.
We assessed the effects of WBM levels on incident CVD among 3083 Greenlandic Inuit, participating in a population-based cohort study conducted from 2005 to 2010. WBM was measured at baseline. Participants were followed in the National Patient Registries for Denmark and Greenland and in the causes of death register for CVD events from inclusion in the study until CVD event, emigration, death or end of follow-up (30/9-2013). Using Cox regression analyses, we calculated the incidence rates and the hazard ratio of CVD events according to WBM levels. Potential interactions with sex were also investigated.
The highest levels of WBM were found in men, who had a significantly higher median level (19 μg/L (IQR:1-44)), compared with women (15 μg/L (IQR: 1-32), (p < 0.001)). The crude hazard ratio (HR) for incident CVD was 1.00 (95% CI 1.00-1.00) for 5 µg/l increase in WBM. After adjusting for several potential confounders, there was still no association between WBM and incident CVD (HR 0.99; 95%CI:0.99-1.00). We found no interactions with sex.
In a population with high levels of WBM, we found no association between WBM and the risk of developing CVD in Greenland.
研究发现汞与心血管疾病（CVD）有关，但主要是在低暴露人群中。全世界全血汞（WBM）的最高水平及其变化在格陵兰发现。我们前瞻性评估了 WBM 水平与格陵兰人群 CVD 发病风险之间的关系。
我们评估了 3083 名格陵兰因纽特人在一项从 2005 年至 2010 年进行的基于人群的队列研究中，WBM 水平对 CVD 事件发生的影响。在基线时测量 WBM。参与者在丹麦和格陵兰的国家患者登记处以及心血管疾病死亡登记处进行随访，从纳入研究开始至 CVD 事件、移民、死亡或随访结束（30/9-2013）。使用 Cox 回归分析，我们根据 WBM 水平计算 CVD 事件的发生率和风险比。还研究了与性别之间的潜在相互作用。
最高的 WBM 水平见于男性，其中位数水平（19μg/L（IQR：1-44））明显高于女性（15μg/L（IQR：1-32），（p<0.001））。WBM 增加 5μg/L 时，CVD 事件的粗风险比（HR）为 1.00（95%CI 1.00-1.00）。在调整了几个潜在的混杂因素后，WBM 与 CVD 事件之间仍然没有关联（HR 0.99；95%CI：0.99-1.00）。我们没有发现与性别之间的相互作用。
在 WBM 水平较高的人群中，我们发现 WBM 与格陵兰 CVD 发病风险之间没有关联。
