青少年吸食水烟与脑源性神经营养因子：伊尔比德试验
Brain-derived neutrophic factor in adolescents smoking waterpipe: The Irbid TRY.
作者信息
Alomari Mahmoud A, Al-Sheyab Nihaya A, Khabour Omar F, Alzoubi Karem H
机构信息
Division of Physical Therapy, Department of Rehabilitation Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, PO Box 3030, Irbid 22110, Jordan.
Faculty of Nursing, Maternal and Child Health Department, Jordan University of Science and Technology, Irbid, Jordan.
出版信息
Int J Dev Neurosci. 2018 Jun;67:14-18. doi: 10.1016/j.ijdevneu.2018.03.007. Epub 2018 Mar 16.
BACKGROUND
Brain-derived neutrophic factor (BDNF) and tobacco consumption can affect many body functions and health. However, the relationship of BDNF with waterpipe (Wp) smoking is unknown. Therefore, the current study examined the relationship between Wp smoking and BDNF in adolescents.
METHODS
Self-reported tobacco consumption and serum BDNF were determined in 195 waterpipe and 288 nonsmokers in 7th-10th grade students.
RESULTS
Stepwise regression that included Wp smoking, gender, BMI, and location, showed that only Wp smoking (p < 0.0001) and gender (p < 0.0001) were related to serum BDNF. In addition, the ANCOVA found a main effect for Wp smoking (p < 0.0001) and gender (p < 0.0001) with lower BDNF in males smoking waterpipe.
DISCUSSION
BDNF was diminished in adolescent Wp smokers, which might predispose adolescents for systematic adverse health and behavioral alterations. These results extend the negative health risks associated with cigarette smoking to that of water-pipe tobacco smoking.
背景
脑源性神经营养因子（BDNF）和烟草消费会影响许多身体功能和健康。然而，BDNF与水烟吸食之间的关系尚不清楚。因此，本研究调查了青少年水烟吸食与BDNF之间的关系。
方法
对7至10年级学生中的195名水烟吸食者和288名非吸烟者进行了自我报告的烟草消费情况及血清BDNF检测。
结果
逐步回归分析纳入了水烟吸食、性别、体重指数（BMI）和地区，结果显示只有水烟吸食（p < 0.0001）和性别（p < 0.0001）与血清BDNF有关。此外，协方差分析发现水烟吸食（p < 0.0001）和性别（p < 0.0001）存在主效应，吸食水烟的男性BDNF水平较低。
讨论
青少年水烟吸食者的BDNF水平降低，这可能使青少年易出现系统性不良健康和行为改变。这些结果将与吸烟相关的负面健康风险扩展到了水烟吸食。
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