撒哈拉以南非洲地区 5 岁以下儿童非血性腹泻中抗生素使用的流行情况及相关因素。
Prevalence and factors associated with the use of antibiotics in non-bloody diarrhoea in children under 5 years of age in sub-Saharan Africa.
机构信息
School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, UK.
Department of Clinical Pharmacy and Pharmacy Management, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
出版信息
Arch Dis Child. 2019 Jun;104(6):518-521. doi: 10.1136/archdischild-2017-314228. Epub 2018 Mar 19.
OBJECTIVES
To estimate the prevalence and determine the factors associated with the use of antibiotics in the management of non-bloody diarrhoea in children under 5 years of age in sub-Saharan Africa (SSA).
METHODS
We conducted a meta-analysis of demographic and health survey data sets from 30 countries in SSA. Pooled prevalence estimates were calculated using random effects model. Χ tests were employed to determine the factors associated with the antibiotic use.
RESULTS
The pooled prevalence of antibiotic use among cases of non-bloody diarrhoea in children under 5 years of age was 23.1% (95% CI 19.5 to 26.7). The use of antibiotics in children with non-bloody diarrhoea in SSA was associated with (p<0.05) the source of care, place of residence, wealth index, maternal education and breastfeeding status.
CONCLUSION
We found an unacceptably high use of antibiotics to treat episodes of non-bloody diarrhoea in children under the age of 5 in SSA.
目的
评估撒哈拉以南非洲（SSA）地区 5 岁以下儿童非血性腹泻管理中使用抗生素的流行情况，并确定相关因素。
方法
我们对 SSA 地区 30 个国家的人口和健康调查数据集进行了荟萃分析。使用随机效应模型计算汇总患病率估计值。采用 χ 检验确定与抗生素使用相关的因素。
结果
5 岁以下非血性腹泻患儿中抗生素使用的汇总患病率为 23.1%（95%CI 19.5 至 26.7）。SSA 地区非血性腹泻儿童使用抗生素与（p<0.05）护理来源、居住地、财富指数、母亲教育程度和母乳喂养状况有关。
结论
我们发现，SSA 地区 5 岁以下儿童非血性腹泻发作时抗生素的使用高得令人无法接受。
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