Beijing Institute of Ophthalmology and Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.
Sci Rep. 2018 Mar 19;8(1):4816. doi: 10.1038/s41598-018-23314-5.
To examine associations between cognitive function and ophthalmological parameters, the population-based Beijing Eye Study examined ophthalmologically and physically 3127 individuals (mean age: 64.2 ± 9.8 years). Using the mini-mental state examination, cognitive function was assessed as cognitive function score (CFS). Mean CFS was 26.3 ± 3.7 (median: 27; range: 2-30). Prevalence of mild (CFS: 23-19), moderate (CFS: 18-10) and severe cognitive dysfunction was 9.6% (95% confidence interval (CI): 8.5, 10.6), 3.2% (95% CI: 2.6, 3.9) and 0.6% (95% CI: 0.4,0.9), respectively. In multivariate analysis, better cognition (i.e., higher CFS) was significantly associated with better best corrected visual acuity (r = 0.38), smaller amount of undercorrected visual acuity, lower prevalence of primary angle-closure glaucoma, and thicker subfoveal choroidal thickness. Prevalence of age-related macular degeneration, open-angle glaucoma, diabetic retinopathy, any type of cataract, retinal vein occlusions or pseudoexfoliation was not significantly correlated with CFS. Though the causal relationship is unclear, the associations of lower cognitive function with undercorrected visual acuity suggest the need for earlier and more regular refraction testing in the elderly so that providing adequate glasses to the elderly can be provided and vision-associated cognitive decline can be reduced. Associations of cognitive function with primary angle-closure glaucoma and leptochoroid should be further explored.
为了研究认知功能与眼科参数之间的关系，这项基于人群的北京眼研究对 3127 名个体（平均年龄：64.2±9.8 岁）进行了眼科和身体检查。使用简易精神状态检查（mini-mental state examination），评估认知功能为认知功能评分（cognitive function score，CFS）。平均 CFS 为 26.3±3.7（中位数：27；范围：2-30）。轻度（CFS：23-19）、中度（CFS：18-10）和重度认知功能障碍的患病率分别为 9.6%（95%置信区间（CI）：8.5，10.6）、3.2%（95% CI：2.6，3.9）和 0.6%（95% CI：0.4，0.9）。多变量分析显示，更好的认知功能（即更高的 CFS）与更好的最佳矫正视力（r=0.38）、更小的未矫正视力量、原发性闭角型青光眼的患病率较低以及更厚的脉络膜下厚度相关。年龄相关性黄斑变性、开角型青光眼、糖尿病性视网膜病变、任何类型的白内障、视网膜静脉阻塞或假性剥脱综合征的患病率与 CFS 无显著相关性。虽然因果关系尚不清楚，但认知功能下降与未矫正视力之间的关联表明，需要对老年人进行更早和更定期的屈光检查，以便为老年人提供足够的眼镜，并减少与视力相关的认知能力下降。认知功能与原发性闭角型青光眼和脉络膜下变薄之间的关联需要进一步探讨。
