Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing, China.
Acta Ophthalmol. 2019 May;97(3):325-331. doi: 10.1111/aos.13962. Epub 2018 Oct 18.
To assess associations between the amount of physical activity and the prevalence of ocular diseases.
The participants of the population-based Beijing Eye Study underwent a detailed ophthalmological examination and an interview. Physical activity was assessed in a standardized questionnaire.
Out of 3468 study participants, information on their physical activity was available for 3031 (87.4%) individuals (age: 64.6 ± 9.7 years; range: 50-93 years). In multivariate analysis (regression coefficient r: 0.41), higher physical activity was associated with a lower prevalence of diabetic retinopathy [p = 0.009; standardized regression coefficient beta: -0.05; non-standardized regression coefficient B: -15.7; 95% confidence interval (CI): -27.6, -3.90] after adjusting for younger age, rural region of habitation, lower level of education, lower blood concentrations of triglycerides and low-density lipoproteins and higher blood concentrations of high-density lipoproteins, higher systolic blood pressure, lower body mass index and lower depression score. Other major ocular diseases such as open-angle glaucoma (p = 0.25), angle-closure glaucoma (p = 0.59), nuclear cataract (p = 0.78), cortical cataract (p = 0.54), posterior subcapsular cataract (p = 0.96), retinal vein occlusions (p = 0.93) and central serous choroidopathy (p = 0.39) were not statistically associated with physical activity in that model. The association between higher physical activity and prevalence of age-related macular degeneration (p = 0.04; β: 0.04; B: 4.87; 95% CI: 0.25, 9.50) was marginally significant.
Higher physical activity and less sedentary lifestyle were associated with a lower prevalence of diabetic retinopathy, while the occurrence of other major ocular diseases such as any type of cataract and of glaucoma, retinal vein occlusions and central serous choroidopathy was statistically independent of physical activity or a more sedentary lifestyle.
评估身体活动量与眼部疾病患病率之间的关联。
该人群为基于人群的北京眼研究的参与者，他们接受了详细的眼科检查和访谈。身体活动量在标准化问卷中进行评估。
在 3468 名研究参与者中，有 3031 名（87.4%）个体的身体活动信息可用（年龄：64.6±9.7 岁；范围：50-93 岁）。在多变量分析（回归系数 r：0.41）中，较高的身体活动量与较低的糖尿病视网膜病变患病率相关（p=0.009；标准化回归系数β：-0.05；未标准化回归系数 B：-15.7；95%置信区间（CI）：-27.6，-3.90），调整因素包括年龄较小、居住在农村地区、教育程度较低、甘油三酯和低密度脂蛋白水平较低、高密度脂蛋白水平较高、收缩压较高、体重指数较低和抑郁评分较低。其他主要眼部疾病，如开角型青光眼（p=0.25）、闭角型青光眼（p=0.59）、核性白内障（p=0.78）、皮质性白内障（p=0.54）、后囊下白内障（p=0.96）、视网膜静脉阻塞（p=0.93）和中心性浆液性脉络膜视网膜病变（p=0.39）在该模型中与身体活动无统计学关联。较高的身体活动量与年龄相关性黄斑变性的患病率之间的关联具有统计学意义（p=0.04；β：0.04；B：4.87；95%CI：0.25，9.50）。
较高的身体活动量和较少的久坐生活方式与较低的糖尿病视网膜病变患病率相关，而其他主要眼部疾病（如任何类型的白内障和青光眼、视网膜静脉阻塞和中心性浆液性脉络膜视网膜病变）的发生与身体活动或更多的久坐生活方式无关。
