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通过组蛋白乙酰化和mRNA延伸因子BRD4-P-TEFb对小鼠小肠中Sglt1昼夜节律性表达的调控

Regulation of the circadian rhythmic expression of Sglt1 in the mouse small intestine through histone acetylation and the mRNA elongation factor, BRD4-P-TEFb.

作者信息

Yamauchi Hiroyuki, Honma Kazue, Mochizuki Kazuki, Goda Toshinao

机构信息

a Laboratory of Nutritional Physiology, Department of Nutrition, Graduate School of Nutritional and Environmental Sciences , University of Shizuoka , Shizuoka , Japan.

b Laboratory of Food and Nutritional Sciences, Faculty of Life and Environmental Sciences, Department of Local Produce and Food Sciences , University of Yamanashi , Yamanashi , Japan.

出版信息

Biosci Biotechnol Biochem. 2018 Jul;82(7):1176-1179. doi: 10.1080/09168451.2018.1451743. Epub 2018 Mar 20.

DOI:10.1080/09168451.2018.1451743
PMID:29557282
Abstract

Jejunal sodium/glucose co-transporter (Sglt1) displays circadian expression. The jejunum was collected every 4 h from mice, and we examined histone acetylation and binding of bromodomain-containing protein-4 (BRD4) around of the gene. Histone acetylation increased in the transcribed region of Sglt1 prior to induction of the gene. Furthermore, the binding of mRNA elongation factor around the gene showed circadian rhythm.

摘要

空肠钠/葡萄糖共转运体（Sglt1）呈现昼夜节律性表达。每隔4小时从小鼠身上采集空肠，并检测该基因周围的组蛋白乙酰化以及含溴结构域蛋白4（BRD4）的结合情况。在该基因诱导表达之前，Sglt1转录区域的组蛋白乙酰化增加。此外，该基因周围的mRNA延伸因子结合呈现昼夜节律。

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