替考霉素A2在豚鼠中无耳毒性。
Absence of ototoxicity of teichomycin A2 in guinea pigs.
作者信息
Brummett R E, Fox K E, Warchol M, Himes D
出版信息
Antimicrob Agents Chemother. 1987 Apr;31(4):612-3. doi: 10.1128/AAC.31.4.612.
Abstract
Teichomycin A2 is a new antibiotic that is similar to vancomycin. Because vancomycin is reported to be ototoxic, teichomycin A2 was tested for ototoxicity. No evidence of ototoxicity was found. Furthermore, ethacrynic acid, a diuretic that augments the ototoxicity of many drugs, did not enhance ototoxicity with teichomycin A2.
摘要
替考拉宁A2是一种类似于万古霉素的新型抗生素。由于据报道万古霉素具有耳毒性，因此对替考拉宁A2进行了耳毒性测试。未发现耳毒性证据。此外，一种能增强许多药物耳毒性的利尿剂依他尼酸，并未增强替考拉宁A2的耳毒性。
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