Parenti F, Beretta G, Berti M, Arioli V
J Antibiot (Tokyo). 1978 Apr;31(4):276-83. doi: 10.7164/antibiotics.31.276.
A soil isolate of Actinoplanes that produces the chemically unrelated new antibiotics teichomycins A1 and A2 has been proposed as a new species named Actinoplanes teichomyceticus nov. sp. (ATCC 31121). Studies of medium and fermentation conditions indicated that the highest antibiotic titers, ca 900 u/ml, are obtained in a medium containing 1% (w/v) glucose, 1% cotton seed meal, 1% malt extract, and 0.4% yeast extract. Both teichomycin A1 and teichomycin A2 are highly active against gram-positive bacteria. Teichomycin A1 shows some activity against gram-negative bacteria. Both antibiotics cured mice experimentally infected with sensitive bacteria and showed low acute toxicity. Of the two antibiotics teichomycin A2 is the more active.
从土壤中分离出的一株游动放线菌能产生化学结构不相关的新抗生素替考拉宁A1和A2，该菌株已被提议作为一个新物种，命名为替考拉宁游动放线菌新种（ATCC 31121）。对培养基和发酵条件的研究表明，在含有1%（w/v）葡萄糖、1%棉籽粉、1%麦芽提取物和0.4%酵母提取物的培养基中，抗生素产量最高，约为900单位/毫升。替考拉宁A1和替考拉宁A2对革兰氏阳性菌均有高度活性。替考拉宁A1对革兰氏阴性菌有一定活性。两种抗生素均能治愈实验性感染敏感菌的小鼠，且急性毒性较低。在这两种抗生素中，替考拉宁A2活性更强。
