Inorganic Chemistry Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QR, UK.
Department of Chemistry, University of Bath, Claverton Down, BA2 7AY, UK.
Chem Soc Rev. 2018 Apr 23;47(8):2554-2571. doi: 10.1039/C7CS00014F.
This Tutorial Review aims to provide an overview of the use of zirconium-89 complexes in biomedical imaging. Over the past decade there have been many new papers in this field, ranging from chemistry through to preclinical and clinical applications. Here we attempt to summarise the main developments that have occurred in this period. The primary focus is on coordination chemistry but other aspects such as isotope production, isotope properties, handling and radiochemical techniques and characterisation of cold and labelled complexes are included. Selected results from animal and human clinical studies are presented in the context of the stabilities and properties of the labelled bioconjugates.
本教程综述旨在概述 89Zr 配合物在生物医学成像中的应用。在过去的十年中，该领域发表了许多新论文，涵盖了从化学到临床前和临床应用的各个方面。本文试图总结这一时期的主要发展。主要重点是配位化学，但也包括其他方面，如同位素生产、同位素性质、处理和放射化学技术以及冷标记和标记配合物的特性。在标记生物缀合物的稳定性和特性的背景下，介绍了来自动物和人体临床研究的部分结果。
