1 INSERM U1093, Univ. Bourgogne Franche-Comté, Dijon, France.
2 Service de Neurologie, CHRU, Dijon, France.
J Cereb Blood Flow Metab. 2018 Jun;38(6):935-949. doi: 10.1177/0271678X18766772. Epub 2018 Mar 20.
Low cerebral levels of brain-derived neurotrophic factor (BDNF), which plays a critical role in many brain functions, have been implicated in neurodegenerative, neurological and psychiatric diseases. Thus, increasing BDNF levels in the brain is considered an attractive possibility for the prevention/treatment of various brain diseases. To date, BDNF-based therapies have largely focused on neurons. However, given the cross-talk between endothelial cells and neurons and recent evidence that BDNF expressed by the cerebral endothelium largely accounts for BDNF levels present in the brain, it is likely that BDNF-based therapies would be most effective if they also targeted the cerebral endothelium. In this review, we summarize the available knowledge about the biology and actions of BDNF derived from endothelial cells of the cerebral microvasculature and we emphasize the remaining gaps and shortcomings.
脑源性神经营养因子（BDNF）在许多大脑功能中发挥着关键作用，其水平较低与神经退行性、神经和精神疾病有关。因此，提高大脑中的 BDNF 水平被认为是预防/治疗各种脑部疾病的一种有吸引力的可能性。迄今为止，基于 BDNF 的治疗方法主要集中在神经元上。然而，鉴于内皮细胞和神经元之间的交流以及最近的证据表明，大脑内皮细胞表达的 BDNF 在很大程度上解释了大脑中存在的 BDNF 水平，基于 BDNF 的治疗方法如果也针对大脑内皮细胞，可能会更有效。在这篇综述中，我们总结了目前关于大脑微血管内皮细胞衍生的 BDNF 的生物学和作用的知识，并强调了仍存在的差距和不足之处。
