Liao Chunxiao, Gao Wenjing, Cao Weihua, Lv Jun, Yu Canqing, Wang Shengfeng, Li Chunxiao, Pang Zengchang, Cong Liming, Dong Zhong, Wu Fan, Wang Hua, Wu Xianping, Jiang Guohong, Wang Xiaojie, Wang Binyou, Li Liming
Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing,China.
Qingdao Center for Diseases Control and Prevention,Qingdao,China.
Twin Res Hum Genet. 2018 Apr;21(2):126-135. doi: 10.1017/thg.2018.8. Epub 2018 Mar 21.
The prevalence of overweight and obesity is growing rapidly in many countries. Socioeconomic inequalities might be important for this increase. The aim of this study was to determine associations of body mass index (BMI), overweight and obesity with educational level and marital status in Chinese twins. Participants were adult twins recruited through the Chinese National Twin Registry (CNTR), aged 18 to 79 years, and the sample comprised 10,448 same-sex twin pairs. Current height, weight, educational attainment, and marital status were self-reported. Regression analyses and structural equation models were conducted to evaluate BMI, overweight, and obesity associated with educational level and marital status in both sexes. At an individual level, both educational level and marital status were associated with higher BMI and higher risk of being overweight and obesity in men, while in women the effects of educational level on BMI were in the opposite direction. In within-Monozygotic (MZ) twin-pair analyses, the effects of educational level on BMI disappeared in females. Bivariate structural equation models showed that genetic factors and shared environmental confounded the relationship between education and BMI in females, whereas marital status was associated with BMI on account of significant positive unique environmental correlation apart in both sexes. The present data suggested that marital status and BMI were associated, independent of familiar factors, for both sexes of this study population, while common genetic and shared environmental factors contributed to education-associated disparities in BMI in females.
在许多国家,超重和肥胖的患病率正在迅速上升。社会经济不平等可能是导致这种增长的重要因素。本研究的目的是确定中国双胞胎群体中体重指数(BMI)、超重和肥胖与教育水平及婚姻状况之间的关联。研究参与者为通过中国国家双胞胎登记系统(CNTR)招募的成年双胞胎,年龄在18至79岁之间,样本包括10448对同性双胞胎。当前的身高、体重、教育程度和婚姻状况均由参与者自行报告。通过回归分析和结构方程模型来评估男女中与教育水平和婚姻状况相关的BMI、超重和肥胖情况。在个体层面,教育水平和婚姻状况在男性中均与较高的BMI以及超重和肥胖的较高风险相关,而在女性中,教育水平对BMI的影响方向相反。在同卵双胞胎(MZ)对内分析中,教育水平对女性BMI的影响消失。双变量结构方程模型显示,遗传因素和共同环境混淆了女性教育与BMI之间的关系,而婚姻状况与BMI相关是由于在男女中均存在显著的正向独特环境相关性。目前的数据表明,在本研究人群中,婚姻状况和BMI相关,且独立于家族因素,而共同的遗传和共同环境因素导致了女性中与教育相关的BMI差异。