表达FcE受体的巨噬细胞对IgE合成的调节：白细胞介素1的作用

Regulation of IgE synthesis by macrophages expressing FcE-receptors: role of interleukin 1.

作者信息

Mazingue C, Carrière V, Dessaint J P, Detoeuf F, Turz T, Auriault C, Capron A

出版信息

Clin Exp Immunol. 1987 Mar;67(3):587-93.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1542631/

Abstract

Triggering rat macrophages with IgE complexes induced the production of interleukin 1-like activity (IL-1). The signal is delivered through the macrophage FcE receptor since stimulating macrophages with IgE bound to spleen cells (to avoid endocytosis) or with an anti-FcE receptor antibody linked to nonphagocytizable cells also led to IL-1 production. The molecular weight of IL-1 produced after IgE triggering is in the same range (30 kD) as previously described for rat IL-1. A positive feed-back effect of IL-1 on IgE response was suggested, as purified IL-1 was able to enhance IgE synthesis in vitro by lymphocytes from immunized animals.

摘要

用IgE复合物刺激大鼠巨噬细胞可诱导白细胞介素1样活性（IL-1）的产生。该信号通过巨噬细胞FcE受体传递，因为用与脾细胞结合的IgE（以避免内吞作用）或与不可吞噬细胞连接的抗FcE受体抗体刺激巨噬细胞也会导致IL-1的产生。IgE触发后产生的IL-1的分子量与先前描述的大鼠IL-1处于相同范围（30 kD）。由于纯化的IL-1能够在体外增强免疫动物淋巴细胞的IgE合成，因此提示IL-1对IgE反应有正反馈作用。

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Secretion of leukotriene C and other arachidonic acid metabolites by macrophages challenged with immunoglobulin E immune complexes.用免疫球蛋白E免疫复合物刺激巨噬细胞后，其白三烯C及其他花生四烯酸代谢产物的分泌情况。

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Int Arch Allergy Appl Immunol. 1984;73(3):225-30. doi: 10.1159/000233472.

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