Langlet C, Mazingue C, Dessaint J P, Capron A
Int Arch Allergy Appl Immunol. 1984;73(3):225-30. doi: 10.1159/000233472.
Schistosome-derived inhibitory factor (SDIF) previously shown to inhibit lymphocyte proliferation, markedly decreased the primary IgE response of rats immunized with dinitrophenylated ovalbumin (DNP-OVA) when injected either simultaneously or shortly after antigen administration. No effect however was observed when SDIF was injected before the immunization. An inhibition of non-IgE anti-DNP antibodies was also found in SDIF-treated rats although the decrease was lower than with IgE antibody. IgE responses of both low and high IgE responder rats were reduced but a lower dose of SDIF was required in the case of high IgE responder Brown Norway rats. When SDIF was only given at the time of priming, the secondary IgE response was no longer modified. However, the administration of SDIF together with the second injection of the antigen induced marked decrease in the secondary IgE response. The effects of SDIF on primary and secondary IgE responses could be attributed to the inhibitory activity of the parasite-derived factor on lymphocyte proliferation. The observed inhibition of secondary IgE antibody responses confers to SDIF a pharmacological interest in allergic diseases.
血吸虫衍生抑制因子（SDIF）先前已被证明可抑制淋巴细胞增殖，在与二硝基苯基化卵清蛋白（DNP-OVA）免疫的大鼠同时注射或在抗原给药后不久注射时，可显著降低其初次IgE反应。然而，在免疫前注射SDIF则未观察到任何效果。在经SDIF处理的大鼠中也发现了非IgE抗DNP抗体的抑制作用，尽管其降低程度低于IgE抗体。低IgE反应大鼠和高IgE反应大鼠的IgE反应均降低，但对于高IgE反应的棕色挪威大鼠，所需的SDIF剂量较低。当仅在初次免疫时给予SDIF时，二次IgE反应不再受到影响。然而，将SDIF与第二次抗原注射一起给药可导致二次IgE反应显著降低。SDIF对初次和二次IgE反应的影响可归因于寄生虫衍生因子对淋巴细胞增殖的抑制活性。观察到的对二次IgE抗体反应的抑制赋予了SDIF在过敏性疾病方面的药理学意义。
