Wen Zehuai, Wei Jia, Xue Huiling, Chen Yunqin, Melnick David, Gonzalez Jesus, Hackett Judith, Li Xiaoyan, Cao Zhaolong
Key Unit of Methodology in Clinical Research, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou.
AstraZeneca R&D Information China, Shanghai, China.
Ther Clin Risk Manag. 2018 Mar 13;14:501-510. doi: 10.2147/TCRM.S143266. eCollection 2018.
The etiology, epidemiology, treatment patterns, and clinical outcomes of neonatal and pediatric pneumonia patients in China are not well reported. This retrospective chart review study aimed to describe such information among neonatal (0 to 27 days) and pediatric (28 days to <18 years) pneumonia patients in two regions of China.
Electronic medical records of pneumonia hospitalizations (aged <18 years) admitted between 2008 and 2013 from four hospitals under Guangdong Provincial Hospital of Chinese Medicine (Southern China) and between 2010 and 2014 at Peking University People's Hospital (Beijing, Northern China) were reviewed.
The average age of neonatal hospitalizations in Beijing (n=92) was 3.5 days. The mean length of hospital stay was 11.2 days, and no deaths occurred. was the most common bacteria found in Beijing patients, whereas was the most common bacteria found in Guangdong patients. The average age of pediatric hospitalizations was 3.3 (±3.1) and 6.5 (±5.6) years in Guangdong (n=3,046) and Beijing (n=222), respectively. The mean length of hospital stay was 17.4 and 5.8 days, and overall mortality rates were 0.2% and 0.5%.
The findings revealed a low level of bacterial isolation and hence microbiological diagnoses. There was a low level of in-hospital mortality due to pneumonia, and the majority of hospitalizations were discharged from hospital, suggesting that current practice was generally effective. Neonatal hospitalizations were greater than pediatric hospitalizations in Beijing along with disparity in bacterial profile when compared with Guangdong, intending a need to improve neonatal pneumonia prophylaxis and selection of appropriate treatment.
中国新生儿及儿童肺炎患者的病因、流行病学、治疗模式及临床结局尚无充分报道。本回顾性病历审查研究旨在描述中国两个地区新生儿(0至27天)及儿童(28天至<18岁)肺炎患者的此类信息。
回顾了广东省中医院下属四家医院(中国南方)2008年至2013年收治的年龄<18岁的肺炎住院患者的电子病历,以及北京大学人民医院(中国北方北京)2010年至2014年收治的此类患者的电子病历。
北京新生儿住院患者(n = 92)的平均年龄为3.5天。平均住院时间为11.2天,无死亡病例。 是在北京患者中发现的最常见细菌,而 是在广东患者中发现的最常见细菌。广东(n = 3,046)和北京(n = 222)儿童住院患者的平均年龄分别为3.3(±3.1)岁和6.5(±5.6)岁。平均住院时间分别为17.4天和5.8天,总体死亡率分别为0.2%和0.5%。
研究结果显示细菌分离水平较低,因此微生物学诊断水平也较低。因肺炎导致的院内死亡率较低,且大多数住院患者出院,这表明当前的治疗方法总体有效。与广东相比,北京的新生儿住院患者多于儿童住院患者,且细菌谱存在差异,这意味着需要加强新生儿肺炎的预防及选择合适的治疗方法。