Keenan Research Centre of the Li Ka Shing Knowledge Institute at St. Michael's Hospital, Neuroscience Research Program, St. Michael's Hospital, Toronto, ON, Canada.
Keenan Research Centre of the Li Ka Shing Knowledge Institute at St. Michael's Hospital, Neuroscience Research Program, St. Michael's Hospital, Toronto, ON, Canada; Faculty of Kinesiology and Physical Education, University of Toronto, Canada.
Neuroimage Clin. 2018 Feb 17;18:518-526. doi: 10.1016/j.nicl.2018.02.011. eCollection 2018.
Concussion is associated with significant adverse effects within the first week post-injury, including physical complaints and altered cognition, sleep and mood. It is currently unknown whether these subjective disturbances have reliable functional brain correlates. Resting-state functional magnetic resonance imaging (rs-fMRI) has been used to measure functional connectivity of individuals after traumatic brain injury, but less is known about the relationship between functional connectivity and symptom assessments after a sport concussion. In this study, rs-fMRI was used to evaluate whole-brain functional connectivity for seventy (70) university-level athletes, including 35 with acute concussion and 35 healthy matched controls. Univariate analyses showed that greater symptom severity was mainly associated with lower pairwise connectivity in frontal, temporal and insular regions, along with higher connectivity in a sparser set of cerebellar regions. A novel multivariate approach also extracted two components that showed reliable covariation with symptom severity: (1) a network of frontal, temporal and insular regions where connectivity was negatively correlated with symptom severity (replicating the univariate findings); and (2) a network with anti-correlated elements of the default-mode network and sensorimotor system, where connectivity was positively correlated with symptom severity. These findings support the presence of connectomic signatures of symptom complaints following a sport-related concussion, including both increased and decreased functional connectivity within distinct functional brain networks.
脑震荡与受伤后第一周内的显著不良影响有关,包括身体不适和认知、睡眠及情绪改变。目前尚不清楚这些主观障碍是否具有可靠的功能性大脑关联。静息态功能磁共振成像(rs-fMRI)已被用于测量创伤性脑损伤后的个体功能连接,但关于运动性脑震荡后功能连接与症状评估之间的关系,了解较少。在这项研究中,rs-fMRI 用于评估 70 名(70)大学水平运动员的全脑功能连接,包括 35 名急性脑震荡患者和 35 名健康匹配对照者。单变量分析表明,更大的症状严重程度主要与额、颞和脑岛区域的成对连接降低有关,而与小脑区域更稀疏的一组连接升高有关。一种新的多变量方法还提取了两个与症状严重程度可靠相关的分量:(1)一个由额、颞和脑岛区域组成的网络,其中连接与症状严重程度呈负相关(复制了单变量发现);(2)一个与默认模式网络和感觉运动系统的反相关元素相关的网络,其中连接与症状严重程度呈正相关。这些发现支持在运动相关脑震荡后存在症状抱怨的连接组学特征,包括在不同的功能大脑网络中存在增加和减少的功能连接。