a Department of Pharmaceutical Biomaterials , School of Pharmacy, Zanjan University of Medical Sciences , Zanjan , Iran.
b Department of Biology, Faculty of Genetics, East Tehran Branch , Islamic Azad University , Tehran , Iran.
Drug Dev Ind Pharm. 2018 Aug;44(8):1377-1384. doi: 10.1080/03639045.2018.1451881. Epub 2018 Mar 23.
Denderimer-modified magnetic nanoparticles are a promising drug delivery nanosystem which can improve the therapeutic efficacy of chemotherapy drugs and can also be beneficial as magnetic resonance (MR) images contrast agent. The present study introduces the preparation and characterization of the potential therapeutic efficiency of curcumin (CUR)-loaded denderimer-modified citric acid coated FeO NPs. Polyamidoamine (PAMAM, generation G) was used to encapsulate citric acid coated FeO nanoparticles. The successful preparation of CUR-loaded nanocarriers were confirmed by X-ray diffraction (XRD), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometer (VSM), and transmission electron microscopy (TEM) techniques. The loading capacity and encapsulation efficiency of CUR molecules were 12 ± 0.03% and 45.58 ± 0.41%, respectively. The anticancer effect of void CUR and CUR-loaded nanocarriers were compared to each other by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on treated MCF-7 cell line. It can be concluded that application of nanoparticles can be more effective strategy for controlled and slow release of CUR in human breast cancer treatment.
树状大分子修饰的磁性纳米粒子是一种很有前途的药物输送纳米系统，它可以提高化疗药物的治疗效果，也可以作为磁共振（MR）图像对比剂。本研究介绍了载姜黄素（CUR）的树状大分子修饰柠檬酸包裹的 FeO 纳米粒子的制备和潜在治疗效果的表征。多聚天冬氨酸（PAMAM，G 代）被用来包裹柠檬酸包裹的 FeO 纳米粒子。载药纳米载体的成功制备通过 X 射线衍射（XRD）、热重分析（TGA）、傅里叶变换红外光谱（FTIR）、振动样品磁强计（VSM）和透射电子显微镜（TEM）技术得到了确认。CUR 分子的载药量和包封率分别为 12±0.03%和 45.58±0.41%。通过对 MCF-7 细胞系进行 3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑溴盐（MTT）测定，比较了载 CUR 纳米载体和无 CUR 对 MCF-7 细胞系的抗癌效果。可以得出结论，纳米粒子的应用可以作为一种更有效的策略，用于控制和缓慢释放 CUR 以治疗人类乳腺癌。
