Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey.
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York.
J Infect Dis. 2018 Jul 2;218(3):355-364. doi: 10.1093/infdis/jiy137.
Control efforts for measles and rubella are intensifying globally. It becomes increasingly important to identify and reach remaining susceptible populations as elimination is approached.
Serological surveys for measles and rubella can potentially measure susceptibility directly, but their use remains rare. In this study, using simulations, we outline key subtleties in interpretation associated with the dynamic context of age-specific immunity, highlighting how the patterns of immunity predicted from disease surveillance and vaccination coverage data may be misleading.
High-quality representative serosurveys could provide a more accurate assessment of immunity if challenges of conducting, analyzing, and interpreting them are overcome. We frame the core disease control and elimination questions that could be addressed by improved serological tools, discussing challenges and suggesting approaches to increase the feasibility and sustainability of the tool.
Accounting for the dynamical context, serosurveys could play a key role in efforts to achieve and sustain elimination.
麻疹和风疹的控制工作在全球范围内正在加强。随着消除工作的推进，识别和接触到剩余的易感人群变得越来越重要。
血清学调查可用于麻疹和风疹的潜在直接测量易感性，但使用仍较为罕见。在这项研究中，我们通过模拟，概述了与特定年龄免疫的动态背景相关的解释中的关键细微差别，强调了从疾病监测和疫苗接种覆盖率数据中预测的免疫模式可能具有误导性。
如果克服了进行、分析和解释血清学调查的挑战，高质量的代表性血清学调查可以更准确地评估免疫。我们提出了可以通过改进血清学工具解决的核心疾病控制和消除问题，讨论了挑战并提出了增加工具可行性和可持续性的方法。
考虑到动态背景，血清学调查可以在实现和维持消除方面发挥关键作用。
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